Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The Effect of Anti-Activin Receptor Type IIA and Type IIB Antibody on Muscle, Bone and Blood in Healthy and Osteosarcopenic Mice.
J Cachexia Sarcopenia Muscle
February 2025
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Background: Anti-Activin Receptor Type IIA and Type IIB antibody (αActRIIA/IIB ab) is a recently developed drug class that targets the activin receptor signalling pathway. Inhibition of receptor ligands (activins, myostatin, growth differentiation factor 11, etc.) can lead to skeletal muscle hypertrophy, bone formation, and increased haematopoiesis.
View Article and Find Full Text PDFBlocking the mineralocorticoid receptor prevents cardiac and mitochondrial dysfunction through the activation of NOX-4 in female hormone deprivation rats.
Acta Physiol (Oxf)
March 2025
Department of Physiological Sciences, Universidade Federal do Espirito Santo, Vitoria, Brazil.
Aim: Young women exhibit lower rates of cardiovascular disease (CVD) than age-matched men, a protective effect often attributed to estrogen's influence on cardiac and mitochondrial function. The risk of CVD increases in post-menopausal women, likely due to estrogen deficiency and aldosterone's negative effects, including those on mitochondria and other cellular targets. This study aimed to explore the link between estrogen deficiency and mitochondrial dysfunction in cardiac health.
View Article and Find Full Text PDF[The influence of yeast β-glucans on the assimilation of vitamins and mineral elements in rats].
Vopr Pitan
January 2025
Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.
Despite the use of yeast β-glucans in food and dietary supplements, there is insufficient data on their effect on the metabolism of vitamins and mineral elements. of the study was to evaluate the effect of β-glucans from Saccharomyces cerevisiae in the diet of growing rats on the absorption of micronutrients in animals deficient in vitamins D, group B and trace elements (iron, copper, zinc). .
View Article and Find Full Text PDF[Development of allergenic potential's assessment approaches of protein hydrolysates obtained from alternative food sources].
Vopr Pitan
January 2025
Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.
The investigation of the perspectives for the application of alternative protein sources in food production has allowed us to identify two main directions requiring comprehensive scientific support: firstly, the development of production and processing of food protein technologies to obtain food hydrolysates with a given composition and properties, and secondly, the assessment of the such product safety, including evaluation of their allergenic potential. Currently, within the second direction, research is being conducted to improve approaches to assessing the allergenic potential of innovative food, search for new in vitro and in vivo models and biomarkers to guarantee the safety of these products for consumers. of the study was to research the allergenic potential of the methanotrophic bacteria protein hydrolysates on the model of systemic anaphylaxis in rats and to formulate approaches to assessing the novel foods' safety.
View Article and Find Full Text PDFExamining Risk Assessment Implications of Genetic and Dose-Dependent Dynamics of Lead Exposure in Breastfeeding Using the Collaborative Cross Mouse Population.
Toxicol Sci
January 2025
Department of Cell Biology and Genetics, Texas A&M University, College Station, TX, USA.
Breastfeeding offers well-documented advantages but may inadvertently introduce lead (Pb) exposure to infants. Scarce data exists on the risks of Pb exposure for breastfed infants, and strategies for risk mitigation are needed, particularly considering the heightened susceptibility of children to adverse effects from Pb exposure. To investigate the potential influence of breastfeeding on blood Pb levels (BLL) in offspring, population variation in BLL between non-parous and parous mouse dams was quantified, as well as in dams exposed to low- and high-dose while breastfeeding, and their offspring.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!