AI Article Synopsis
- The study investigates the toxic effects of various organochalcogens on liver, kidney, and metabolic profiles in mice.
- Diorganotellurium dichloride phosphonate (C1) did not affect liver enzyme levels, while two other compounds (C2 and C3) increased these levels and showed changes in glucose metabolism.
- The findings indicate that organochalcogen compounds can lead to liver and kidney toxicity, as well as disrupt glycemic control, potentially leading to serious health issues.
Article Abstract
In this study we have examined the in vivo toxic effects of various organochalcogens on hepatic, renal, glycemic and lipid profile. Diorganotellurium dichloride phosphonate (C1) at all tested doses did not modify serum alanine aminotransferase (ALT) activity in mice. While, 2-butyltellurium furan (C2) and dinaphthalene ditelluride (C3) at a dose of 0.75 and 0.125 mmol/kg caused an increase in aspartate aminotransferase (AST) and ALT activities. Our data showed that C1 caused an increase in urea content at different doses while treatment with C2 and C3 did not modify urea content. Treatment with C2 caused a significant alteration in serum glucose and fructosamine levels which explains the possible toxicity of these compounds. No significant changes were observed for cholesterol and triglycerides levels. These results suggest that organochalcogen compounds presented liver and renal toxicity and also altered glycemic profile which may leads to various clinical complications.
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| http://dx.doi.org/10.1016/j.etap.2013.07.001 | DOI Listing |
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