AI Article Synopsis
- HippDB is a comprehensive database that catalogs protein-protein interactions featuring helices at their interfaces, leveraging data from the Protein Data Bank.
- Users can query the database based on helix length, sequence, and get computational analyses like alanine scanning and solvent-accessible surface area changes.
- The database is freely accessible online, built using PHP, MySQL, and Apache, with source code available for download for further development.
Article Abstract
Summary: HippDB catalogs every protein-protein interaction whose structure is available in the Protein Data Bank and which exhibits one or more helices at the interface. The Web site accepts queries on variables such as helix length and sequence, and it provides computational alanine scanning and change in solvent-accessible surface area values for every interfacial residue. HippDB is intended to serve as a starting point for structure-based small molecule and peptidomimetic drug development.
Availability And Implementation: HippDB is freely available on the web at http://www.nyu.edu/projects/arora/hippdb. The Web site is implemented in PHP, MySQL and Apache. Source code freely available for download at http://code.google.com/p/helidb, implemented in Perl and supported on Linux.
Contact: arora@nyu.edu.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799476 | PMC |
| http://dx.doi.org/10.1093/bioinformatics/btt483 | DOI Listing |
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