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Structural design and biomechanical analysis of a combined titanium and polyetheretherketone cage based on PE-PLIF fusion.
Med Biol Eng Comput
October 2024
Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Article Synopsis
- The study explores the biomechanical performance of a newly designed spinal fusion cage compared to traditional titanium and PEEK cages, highlighting the drawbacks of stress shielding and poor bone ingrowth associated with the former materials.
- Using finite element analysis, the new combined cage showed a 9.5% increase in strain capacity and reduced endplate and fusion stresses by 12% and 17%, respectively, during dynamic movements.
- The findings indicate that the combined cage may improve fusion stability and reduce adverse effects tied to titanium cages, offering insights for better clinical cage designs in spinal fusion surgeries.
Glucose-primed PEEK orthopedic implants for antibacterial therapy and safeguarding diabetic osseointegration.
Biomaterials
December 2023
School of Chemical Engineering, College of Biomedical Engineering, West China Hospital of Stomatology, Sichuan University, Chengdu, 610065, China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China. Electronic address:
Diabetic infectious microenvironment (DIME) frequently leads to a critical failure of osseointegration by virtue of its main peculiarities including typical hyperglycemia and pathogenic infection around implants. To address the plaguing issue, we devise a glucose-primed orthopedic implant composed of polyetheretherketone (PEEK), Cu-chelated metal-polyphenol network (hauberk coating) and glucose oxidase (GOx) for boosting diabetic osseointegration. Upon DIME, GOx on implants sostenuto consumes glucose to generate HO, and Cu liberated from hauberk coating catalyzes the HO to highly germicidal •OH, which massacres pathogenic bacteria through photo-augmented chemodynamic therapy.
View Article and Find Full Text PDFAn HA/PEEK scaffold with modified crystallinity via 3D-bioprinting for multiple applications in hard tissue engineering.
Biomed Mater
October 2023
State Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Hard tissues, especially teeth and bones, are highly mineralized and the large-scale defect or total loss of them is irreversible. There is still no ideal strategy for the reconstruction of various hard tissue defects that can achieve the balance between biological and mechanical properties. Polyether ether ketone (PEEK) has the potential to substitute for natural hard tissue in defect areas but is limited by its biological inertness.
View Article and Find Full Text PDFEvolving technology: the TRIFLO tri-leaflet mechanical valve without oral anticoagulation: a potential major innovation in valve surgery.
Front Cardiovasc Med
September 2023
Mayo Clinic Rochester, Rochester, MN, United States.
The aortic valve is the most frequently diseased valve and aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries. The diseased native aortic valve can be replaced by either a biological or mechanical valve prosthesis. The main concerns relate to durability, the need for oral anticoagulants and the incidence of complications related to this medication.
View Article and Find Full Text PDFImplant Materials for Anterior Column Reconstruction of Cervical Spine Tumor.
Orthop Surg
May 2023
Department of Orthopaedics, Peking University Third Hospital, Beijing, China.
The spine is the most common site of bone metastases. Many cancer patients will ultimately develop spinal metastatic disease with symptomatic epidural spinal cord compression. At present, the main treatment for cervical spine tumors is surgical resection combined with postoperative radiotherapy.
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