A new method has been developed for the construction of dihydrobenzofurans from O-aryloxime ethers bearing an α-cyano group using a sequential regioselective isomerization/[3,3]-sigmatropic rearrangement/cyclization reaction in MeOH without any catalysts under neutral conditions at ambient temperature. The current transformation provides environmentally benign and atom-economical access to a variety of dihydrobenzofurans containing a quaternary carbon from readily available cyclic and acyclic oxime ethers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol401897u | DOI Listing |
Publication Analysis
Top Keywords
dihydrobenzofurans quaternary
8
quaternary carbon
8
neutral conditions
8
synthesis dihydrobenzofurans
4
carbon center
4
center mild
4
mild neutral
4
conditions method
4
method developed
4
developed construction
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!