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Unusual paraneoplastic neurological presentation associated with multiple myeloma.
BMJ Case Rep
December 2024
Internal Medicine - Hematology/Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Article Synopsis
- A man in his mid-40s faced a decline in vision and gait over six months, leading to the discovery of multiple myeloma as the underlying cause.
- Medical examinations revealed neurological issues consistent with upper motor neuron problems, while imaging confirmed damage to the corticospinal tract and optic nerve.
- The patient improved significantly after treatment for multiple myeloma, highlighting the potential for paraneoplastic neurological syndromes in blood cancers and the need for thorough evaluations in such cases.
Optic Disc Infiltration as a Sign of Multiple Myeloma Recurrence.
J Hematol
August 2024
2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Article Synopsis
- Multiple myeloma is a type of cancer affecting plasma cells, with an incidence of 3-4 per 100,000 in Caucasians and is the second most common blood cancer after non-Hodgkin lymphoma.
- A case study is presented of a 62-year-old woman with a history of multiple myeloma who experienced vision problems and other symptoms, leading to the discovery of ocular involvement as a sign of cancer recurrence.
- Despite no abnormalities found in MRI, the elevated intracranial pressure and presence of cancer cells in the spinal fluid confirmed the diagnosis, and after treatment, her vision improved significantly.
An 84-Year-Old Man with a History of Myeloma and Biphosphonate-Related Osteonecrosis of the Jaw Treated with Preoperative Vascular Embolization Before Partial Maxillectomy.
Am J Case Rep
July 2024
Division of Oral Rehabilitation, Department of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka City, Fukuoka, Japan.
BACKGROUND Bisphosphonates and anti-receptor activator of nuclear factor kappa B antibodies are used to treat bone diseases associated with increased osteoclast activity, including myeloma. However, they can cause osteonecrosis of the jaw, known as medication-related osteonecrosis of the jaw. This report presents a case of a patient with a history of myeloma who required posterior maxilla resection for bisphosphonate-related osteonecrosis of the jaw, in which preoperative embolization prevented unexpected bleeding related to vascular injury and allowed for a safe procedure with minimal bleeding.
View Article and Find Full Text PDFArticle Synopsis
- Multiple myeloma is a common type of cancer affecting plasma cells, typically resulting in bone damage, while osteosclerotic myeloma is a rare form often linked to specific syndromes like POEMS.
- A case study of a 46-year-old woman revealed unusual osteosclerotic changes in her skull, prompting extensive imaging and testing that showed no signs of associated tumors or syndromes, but indicated plasma cell involvement.
- The diagnosis determined was monoclonal gammopathy of clinical significance with osteosclerosis, suggesting a unique form of myeloma that doesn't fit the typical presentation of the disease.
Extramedullary plasmacytoma of the orbit complicating the evolution of multiple myeloma in complete remission.
Leuk Res Rep
April 2024
Hematology Department, Fattouma Bourguiba Hospital of Monastir, Avenue Farhat Hached, Monastir 5000, Tunisia.
Orbital plasmacytoma is rare and has only been reported in the context of the initial diagnosis of multiple myeloma. Moreover, isolated orbital plasmacytoma without any signs of multiple myeloma is extremely rare. We report the case of a 59-year-old female patient diagnosed with IgA Kappa multiple myeloma.
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