Measles is a highly infectious disease with a high reproduction rate [1]. For every index case occurring in a susceptible population, 15–17 secondary cases will occur [1]. The most effective way to control measles is by active immunization of a high proportion of the population [2]. MMR vaccine was introduced in the UK in October 1988 and achieved coverage levels in excess of 90% [3]. Prior to this measles vaccination coverage was low and transmission was largely unaffected. According to seroprevalence studies <1% of individuals born before 1970 and <10% born between 1970 and 1989 are antibody negative to measles [4, 5]; however, despite measles vaccination programmes residual susceptibility is present in young adults [6]. We describe an outbreak of measles occurring in a prison in Yorkshire that began in December 2012.
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http://dx.doi.org/10.1017/S0950268813002008 | DOI Listing |
Nursing
December 2024
Dorothy Borton is an independent infection prevention consultant based in Philadelphia, Pa., and a member of the Nursing2024 Editorial Board.
Measles (rubeola) cases and outbreaks have increased worldwide in 2023 and 2024. This article provides a comprehensive overview of the global resurgence of measles cases, highlighting the critical role of vaccination in preventing outbreaks. It also discusses the factors contributing to declining vaccination rates, the implications for public health, and immediate infection control measures in the event of suspected cases.
View Article and Find Full Text PDFJ Virol
January 2025
Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Measles virus (MeV) is a highly contagious respiratory virus transmitted via aerosols. To understand how MeV exits the airways of an infected host, we use unpassaged primary cultures of human airway epithelial cells (HAE). MeV typically remains cell-associated in HAE and forms foci of infection, termed infectious centers, by directly spreading cell-to-cell.
View Article and Find Full Text PDFJ Infect
January 2025
Bandim Health Project, Research Unit OPEN, Department of Clinical Research, University of Southern Denmark, Odense C, Denmark; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Objectives: To investigate if receipt of measles-mumps-rubella (MMR) vaccine following the third dose of diphtheria-tetanus-acellular pertussis (DTaP3) is associated with reduced rates of non-targeted infectious disease hospitalisations.
Methods: Register based cohort study following 1,397,027 children born in Denmark, Finland, Norway, and Sweden until 2 years of age. Rates of infectious disease hospitalisations with minimum one overnight stay according to time-varying vaccination status were compared using Cox proportional hazards regression analysis with age as the underlying timescale and including multiple covariates.
Vaccines (Basel)
December 2024
National Centre for Epidemiology, Institute of Health Carlos III, 28029 Madrid, Spain.
Background/objectives: Spain has been in a measles elimination phase since 2014. No evidence exists about the distribution of measles cases among the population born outside Spain. The aim of this study was thus to describe the epidemiological situation of measles, stratified by place of birth, during the post-elimination period in Spain.
View Article and Find Full Text PDFVaccines (Basel)
November 2024
Department of Immunization, Vaccines and Biologicals, World Health Organization, 1202 Geneva, Switzerland.
In 2015, the 62nd session of the Regional Committee [RC] of the Eastern Mediterranean Region [EMR] endorsed the Eastern Mediterranean Vaccine Action Plan 2016-2020 (EMVAP) that included postponement of the measles elimination target to before 2020. However, the EMR does not have a regional rubella control or elimination goal. We reviewed the progress of measles and rubella surveillance in context of measles elimination in the Eastern Mediterranean Region during 2019-2022.
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