Background: Given the problems associated with the escalation in methamphetamine (METH) use, the identification of more effective treatment strategies is essential. Group II metabotropic glutamate receptors (mGluRs) have been suggested to be a novel therapeutic target for psychostimulant addiction. We sought to test the ability of the selective group II mGluR agonist LY379268 to reduce METH self-administration in rats.
Methods: Rats were trained to self-administer METH on a progressive ratio (PR) schedule. Animals were then switched to fixed ratio responding and given daily extended access (6 h/day) to METH self-administration for 14 days. Rats were then re-tested on the PR schedule. The effect of LY379268 on METH-reinforced PR responding was determined before and after 14 days of extended access. To test for non-specific effects, a separate group of animals received LY379268 prior to a sucrose pellet-reinforced PR schedule.
Results: Animals escalated their daily intake of METH during extended access. PR responding did not change as a function of extended access. LY379268 significantly attenuated METH reinforced responding, both before and after extended access. The degree of attenuation did not change as a function of extended access. LY379268 had no effect on sucrose pellet-reinforced responding at any dose.
Conclusions: LY379268 selectively reduced the motivation to self-administer METH. In contrast to data with other compounds, the sensitivity to the effects of LY379268 did not change following extended access to METH self-administration. Group II mGluR agonists, therefore, may represent a relatively new class of compounds for the development of pharmacotherapies for METH addiction.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804156 | PMC |
| http://dx.doi.org/10.1016/j.drugalcdep.2013.07.024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of a transverse perineal approach to the canine vagina and vestibule.
Front Vet Sci
January 2025
Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, United States.
There are a variety of surgical conditions impacting the canine vagina and vestibule that require access through a caudal approach. A standard vertical episiotomy involves making an incision beginning ventral to the anus and extending ventrally through the dorsal commissure of the vulva and into the lumen of the vestibule and distal vagina. The objective of this study was to determine if complex vaginal procedures could be performed via a transverse perineal approach, thus eliminating the need to incise and reconstruct the vulva as performed in a standard episiotomy, and to evaluate the feasibility of vaginal resection with vulvar-sparing vestibular urethrostomy using this transverse approach.
View Article and Find Full Text PDFBackground Diarrhea is defined as three or more loose or watery bowel movements per day and any additional bowel motions that mothers deem abnormal or extra frequent in children. It is important to note that among children in underdeveloped countries, diarrhea is one of the main causes of illness and death. Severe diarrhea causes significant fluid loss and can be fatal.
View Article and Find Full Text PDFSurgical Management of Gestational Gigantomastia: A Case Report Highlighting Therapeutic Intervention.
Plast Reconstr Surg Glob Open
January 2025
Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Gigantomastia is an exceedingly rare condition characterized by extraordinary growth of breasts during pregnancy, and its underlying etiology remains elusive. Although surgical intervention is the primary treatment modality, there have been emerging prospects for utilizing adjunctive medical therapies, such as bromocriptine, to address this challenging condition. Herein, we report the case of a 26-year-old woman who experienced abrupt and asymmetric bilateral breast enlargement commencing in the second month of her pregnancy.
View Article and Find Full Text PDFPredictors of COVID-19 Readmission Among Patients Previously Hospitalized for SARS-CoV-2.
Infect Dis Ther
January 2025
Department of Pathophysiology and Transplantation, University of Milan, Via Francesco Sforza, 35, 20122, Milan, Italy.
Introduction: Predictors of coronavirus disease 2019 (COVID-19)-related rehospitalization remain underexplored. This study aims to identify the main risk factors associated with rehospitalizations due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections among residents of Lombardy, northern Italy.
Methods: A retrospective observational study was conducted using two linked administrative databases covering demographic data, comorbidities, hospital records, and COVID-19 data of Lombardy residents.
A novel IoT-based approach using fractional fuzzy Hamacher aggregation operators application in revolutionizing healthcare selection.
Sci Rep
January 2025
Department of Management Information Systems, Faculty of Economics and Administration, King Abdulaziz University, Jeddah, Saudi Arabia.
In the current era, IoT-based healthcare solutions play a pivotal role in transforming the healthcare landscape by addressing key challenges and significantly enhancing the quality, accessibility, and efficiency of medical services, particularly for individuals in remote areas. This paper introduces innovative operations on fractional fuzzy sets (FFS), specifically the Hamacher sum and product, and establishes corresponding operational laws. Building upon these foundations, we propose novel aggregation operators (AoPs) leveraging Hamacher norms and rigorously analyze their properties within the FFS framework.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!