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Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters.
Arch Toxicol
January 2025
Cosmetics Europe, Brussels, Belgium.
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances of concern among the broad chemical universe under REACH. Such grouping is usually based on shared structural features and should only be used for the prioritization objectives. However, additional considerations (as well as structural similarity) are needed, e.
View Article and Find Full Text PDFA systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy.
Drug Deliv
December 2025
University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary.
Drug-loaded liposomes incorporated in nanofibrous scaffolds is a promising approach as a multi-unit nanoscale system, which combines the merits of both liposomes and nanofibers (NFs), eliminating the drawback of liposomes' poor stability on the one hand and offering a higher potential of controlled drug release and enhanced therapeutic efficacy on the other hand. The current systematic review, which underwent a rigorous search process in PubMed, Web of Science, Scopus, Embase, and Central (Cochrane) employing (Liposome AND nanofib* AND electrosp*) as search keywords, aims to present the recent studies on using this synergic system for different therapeutic applications. The search was restricted to original, peer-reviewed studies published in English between 2014 and 2024.
View Article and Find Full Text PDFTopical formulation of Boswellia nano emulsion in psoriasis mouse model.
Arch Dermatol Res
December 2024
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Article Synopsis
- Psoriasis is an autoimmune skin disease, and Boswellia serrata (BS) gum resin shows potential in managing inflammatory conditions, although its effectiveness is limited due to poor absorption in the body.
- The study tests a new formulation of Boswellia called Boswellia nano emulsion gel (BNG) on mice with dermatitis induced to resemble psoriasis, finding that BNG significantly reduces inflammation and the associated symptoms.
- Results indicated that treatment with BNG lowers gene expression linked to inflammation compared to control groups, suggesting its therapeutic potential, but more clinical studies are needed to confirm these findings in humans.
Shortened Fornix Syndrome After Posterior-Approach Ptosis Repair.
Ophthalmic Plast Reconstr Surg
December 2024
Division of Oculofacial Plastic and Reconstructive Surgery, Shiley Eye Institute, UCSD, La Jolla, California, U.S.A.
Purpose: To describe and characterize shortened fornix syndrome (SFS), a rare complication following posterior-approach ptosis repair using conjunctival Müller muscle resection.
Methods: This retrospective case series evaluates 4 patients who developed SFS after conjunctival Müller muscle resection. Clinical characteristics, surgical histories, management, and outcomes are reviewed.
Evaluation Of Maternal And Fetal Findings In Patients With Pemphigoid Gestationis.
Int J Gynaecol Obstet
December 2024
Department of Obstetrics and Gynecology, Private Clinic, Kocaeli, Turkey.
Objective: To evaluate the maternal and fetal outcomes of 12 pregnant women diagnosed with pemphigoid gestationis, in conjunction with a review of the literature.
Methods: A retrospective review was conducted on the medical records of 12 patients diagnosed with pemphigoid gestationis who presented between January 2014 and January 2024.
Results: Twelve pregnant patients with pemphigoid gestationis were included in the study.
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