Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1513/AnnalsATS.201305-126CR | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Disruption of the C5a/C5aR1 axis confers protection against hookworm infection in lung.
Front Immunol
December 2024
Pulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, United States.
Article Synopsis
- * The study focused on the role of the complement anaphylatoxin C5a in hookworm infection during the early lung stage, revealing that C5aR1 mice had a reduced burden of hookworms and less lung damage compared to regular mice.
- * Results showed that C5aR1 signaling in neutrophils plays a complex role in response to hookworm infections, highlighting an unexpected downside of complement activation in fighting parasites.
Biologics in allergology and clinical immunology: Update on therapies for atopic diseases, urticaria, and angioedema and on safety aspects focusing on hypersensitivity reactions.
Allergol Select
November 2024
Institute of Allergology, Charité Universitätsmedizin Berlin und Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin.
Article Synopsis
- Targeted therapies using biologics for atopic diseases, urticaria, and angioedema are advancing quickly, with several new antibodies developed, tested, and approved for clinical use, like omalizumab and dupilumab.
- There is ongoing research into combining different biologics for enhanced treatment efficacy, expanding their applications to conditions like food allergies and eosinophilic esophagitis.
- There are emerging concerns about unexpected side effects and hypersensitivity reactions associated with these therapies, raising important questions about their safety and mechanisms, particularly in specific patient groups like children.
Gestational Pemphigoid-From Molecular Mechanisms to Clinical Outcomes: A Case Report and Review of Literature.
Life (Basel)
November 2024
Department of Dermatology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Gestational pemphigoid is a rare, autoimmune, subepidermal bullous disease with an incidence of 1 in 50,000 pregnancies, displaying itself through pruritic erythema and urticarial papules and plaques that evolve into tense bullae. Histopathological findings consist of subepidermal vesicles with perivascular eosinophils and lymphocytes, and direct immunofluorescence reveals C3 complement and, more rarely, IgG in a linear band along the basement membrane. The course is usually self-limiting within 6 months after delivery but, later, can be triggered by subsequent pregnancies, menstruation, or treatment with oral contraceptives.
View Article and Find Full Text PDFUnexpected Multiple Gastrointestinal Cancers in a Patient with Chronic Eosinophilia: A Case Report.
J Gastrointest Cancer
November 2024
Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China.
Purpose: While the relationship between eosinophilia and tumors has been extensively studied, eosinophilia is primarily observed clinically after tumor development, with no prior reports of eosinophilia occurring before tumor onset. This case report presents a unique instance of eosinophilia preceding the development of gastric cancer in an old male patient.
Methods: The patient was evaluated after being diagnosed with gastric cancer.
Unexpected Discoveries: Eosinophilia Masking Splenic Microfilariasis in a Young Woman.
Turk J Haematol
December 2024
YB Chavan College of Pharmacy, Department of Pharmaceutics, Aurangabad, India
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!