AI Article Synopsis
- Influenza leads to significant health issues, particularly in the elderly, many of whom fail to develop adequate antibody protection despite vaccination.
- A study examined high-risk individuals with different Human Leukocyte Antigen (HLA) class II types to see how these alleles influence immune response to the vaccine.
- Results indicated that those with specific HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles had better antibody responses, suggesting that these genetic factors play a role in vaccine effectiveness.
Article Abstract
Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739771 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071376 | PLOS |
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