Samaniego et al. (this issue) report on distinct tumor-associated mesenchymal cell (MC) populations in human melanomas. FAP(-)CD90(+) peritumoral MCs may be involved in immune cell recruitment from the bloodstream. FAP(+)CD90(-) intratumoral MCs were associated with extracellular matrix fiber deposition, and their numbers correlated with high immune cell infiltration. Thus, different MC subsets modulate the cellular composition of the intratumoral and peritumoral melanoma microenvironment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/jid.2013.206 | DOI Listing |
Publication Analysis
Top Keywords
immune cell
12
cell recruitment
8
mesenchymal cells
4
cells hold
4
hold key
4
key immune
4
cell
4
recruitment migration
4
migration melanoma
4
melanoma samaniego
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!