A ligand-free copper-catalyzed tandem azide-alkyne cycloaddition (CuAAC), Ullmann-type C-N coupling, and intramolecular direct arylation has been described. The designed strategy resulted in the synthesis of a novel trazole-fused azaheterocycle framework. The reaction gave good yields (59-77%) of 1,2,3-triazole-fused imidazo[1,2-a]pyridines in a single step.
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Article Synopsis
- A new method was created to combine alkynylphenols with epoxides and elemental sulfur or selenium using a copper catalyst, resulting in a unique 3-chalcogen-benzofuran structure.
- This process operates as a domino reaction, meaning it occurs in one go without needing to isolate or purify intermediates.
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