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The impact of multidisciplinary collaborative bundled care on analgesia and sedation in ICU patients with endotracheal intubation.
Medicine (Baltimore)
December 2024
The First Affiliated Hospital of Soochow University, Suzhou, China.
Background: Effective analgesia and sedation management play a crucial role in reducing the intensity of coughing in patients with endotracheal intubation and improving clinical outcomes. However, current approaches are predominantly singular and lack comprehensive management strategies based on multidisciplinary collaboration. This study aims to evaluate the impact of multidisciplinary collaborative bundled care on analgesia and sedation in intensive care unit (ICU) patients with endotracheal intubation, providing evidence to inform clinical practice.
View Article and Find Full Text PDFDexmedetomidine is Associated with Reduced In-Hospital Mortality Risk of Patients with Subarachnoid Hemorrhage Undergoing Surgery.
World Neurosurg
December 2024
Department of Anaesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China. Electronic address:
Article Synopsis
- The study examines the impact of sedatives, especially dexmedetomidine, on in-hospital mortality rates in patients with subarachnoid hemorrhage (SAH).
- The analysis utilized data from the MIMIC-IV database and found that dexmedetomidine significantly reduced in-hospital mortality compared to other sedatives like propofol and midazolam.
- The research concluded that choosing the right sedative is crucial in managing SAH, as dexmedetomidine not only improves outcomes but also shows a protective effect mediated by creatinine levels.
The Role of Ibuprofen and Midazolam in Pediatric Dentistry: A Retrospective Study and Neurophysiological Considerations.
Brain Sci
October 2024
Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, CH-3010 Bern, Switzerland.
Managing anxiety and behavior during pediatric dental procedures is challenging. This study examines the effects of combining ibuprofen with midazolam sedation using both behavioral management and clinical hypnosis to improve patient cooperation and reduce post-treatment pain. A retrospective cohort study of 311 children (mean age 74.
View Article and Find Full Text PDFNE contribution to rebooting unconsciousness caused by midazolam.
Elife
November 2024
Department of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- Midazolam is a medication with hypnotic and sedative effects, important for various clinical uses, but its exact action on consciousness is not fully understood.
- Research using advanced techniques like pharmacology and optogenetics has identified the locus coeruleus-ventrolateral preoptic nucleus noradrenergic neural circuit as key to how midazolam affects consciousness, particularly through α1 adrenergic receptors.
- The study highlights the GABAA receptor as a critical site for midazolam's action, offering new insights that could improve understanding and management of consciousness recovery in medical settings.
Effect of intraoperative dexmedetomidine on heart-type fatty acid binding protein, CK-MB, and cardiac troponin I levels, and postoperative delirium in patients with heart valve replacement.
Am J Transl Res
October 2024
Department of Anesthesiology and Perioperative Medicine, Xingyuan Hospital of Yulin/4th Hospital of Yulin No. 33 Xirenmin Road, Yuyang District, Yulin 719000, Shaanxi, China.
Objective: This retrospective study aimed to evaluate the impact of intraoperative dexmedetomidine on myocardial injury markers (heart-type fatty acid binding protein [H-FABP], creatine kinase-mb [CK-MB], and cardiac troponin I [cTnI]) and postoperative delirium in patients undergoing heart valve replacement.
Methods: Clinical data from 160 cardiac patients who underwent heart valve replacement with cardiopulmonary bypass (CPB) between January 2019 and January 2024 were analyzed. Patients were divided into an observation group (n = 82) receiving dexmedetomidine and a control group (n = 78) without dexmedetomidine.
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