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Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors. | LitMetric

AI Article Synopsis

  • The study aimed to evaluate the risk factors for hepatocellular carcinoma (HCC) in patients with type C liver disease by analyzing histopathological findings.
  • Researchers categorized 232 patients into two groups based on their liver fibrosis stages and monitored the incidence of HCC, finding a significant difference between the lower fibrosis group and the higher fibrosis group.
  • The presence of atypical hepatocytes in patients with advanced fibrosis was linked to a notably higher risk of developing HCC, highlighting the importance of liver fibrosis progression and specific cellular changes as risk factors.

Article Abstract

Aim: To evaluate the histopathological findings of type C liver disease to determine risk factors for development of hepatocellular carcinoma (HCC).

Methods: We studied 232 patients, who underwent liver biopsy for type C chronic liver disease between 1992 and 2009, with sustained virological response (SVR) after interferon therapy. The patients were divided into two groups according to the F stage 0 + 1 + 2 group (n = 182) and F3 + 4 group (n = 50). We prospectively observed and compared the incidence of HCC of the patients with SVR in the F0 + 1 + 2 and F3 + 4 groups. Then, the background factors and liver histopathological findings, including the degree of fibrosis, F stage, inflammation, necrosis, bile duct obstruction, fat deposition, and degree of irregular regeneration (IR) of hepatocytes, were correlated with the risk of developing HCC.

Results: HCC developed in three of 182 (1.6%) patients in the F0 + 1 + 2 group, and four of 50 (8.0%) in the F3 + 4 group. The cumulative incidence of HCC in the former group was found to be significantly lower than in the F3 + 4 group (log rank test P = 0.0224). The presence of atypical hepatocytes among IR of hepatocytes in the F3 + 4 group resulted in a higher cumulative incidence of HCC, and was significantly correlated with risk of HCC development (RR = 20.748, 95%CI: 1.335-322.5, P = 0.0303).

Conclusion: Atypical hepatocytes among the histopathological findings of type C liver disease may be an important risk factor for HCC development along with progression of liver fibrosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740418PMC
http://dx.doi.org/10.3748/wjg.v19.i30.4887DOI Listing

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