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Partner protections in HIV cure-related trials involving analytical treatment interruption: Updated toolkit to mitigate HIV transmission risk.
J Virus Erad
September 2024
University of California, San Francisco (UCSF), Division of HIV, Infectious Diseases, and Global Medicine, 1001 Potrero Avenue, San Francisco, CA, 94110, USA.
Analytical treatment interruptions (ATIs) are widely used to evaluate HIV cure-related research interventions. However, sex partners of cure-related trial participants might be at risk of acquiring HIV during ATIs. Addressing this risk is key to ensuring the continued success of trials involving ATIs and offer greater acceptability across multiple trials sites.
View Article and Find Full Text PDFA blueprint most wonderful, the homeobox discovery.
Development
March 2024
Department of Molecular Biology, Princeton University, 119 Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544-1014, USA.
This is a personal, non-linear summary of the discovery of the homeobox, a short DNA sequence encoding a DNA-binding domain conserved in developmental control genes. It is based on our recollections, a few decaying lab notebooks and letters, the early research papers we published, and conversations with a few colleagues who were in Basel at the time. It presents a simple story, when the research we did was anything but, with failed experiments, blind alleys and dumb ideas.
View Article and Find Full Text PDFData to knowledge to improvement: creating the learning health system.
BMJ
January 2024
George Washington University, Washington, DC, USA.
detail key domains, tools, and actions required to enact learning health systems for continuous intelligent improvement in healthcare
View Article and Find Full Text PDFProfiles of GPs with high and low self-reported physician empathy-personal, professional, and antibiotic prescribing characteristics.
BMC Prim Care
September 2022
Department of Family Medicine and Public Health, University of California San Diego, 9500 Gilman Drive MC 0965, La Jolla, CA, 92093, USA.
Background: General Practitioners' (GPs) professional empathy has been hypothesized to have substantial impact on their healthcare delivery and medication prescribing patterns. This study compares profiles of personal, professional, and antibiotic prescribing characteristics of GPs with high and low empathy.
Methods: We apply an extreme group approach to a unique combined set of survey and drug register data.
Ira Remsen, Osler, the Flexner Report, and the full-time plan.
Proc (Bayl Univ Med Cent)
March 2021
McGill University Faculty of Medicine, Montreal, Quebec, Canada.
A famous letter from Sir William Osler to Ira Remsen, dated September 1, 1911, concerns Osler's objections to the full-time plan, whereby clinical professors should focus on research and abstain from private practice. Previous accounts of this well-known episode make little or no mention of the recipient other than his being president of the Johns Hopkins University. Remsen, in retrospect, was uniquely positioned to champion ideas advanced by Abraham Flexner, the General Education Board of the Rockefeller Foundation, and some of Osler's former colleagues at Johns Hopkins, notably William H.
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