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Further evidence that a specific homozygous variant results in non-syndromic maculopathy and can be mistaken for prior ocular toxoplasmosis infection.
Ophthalmic Genet
January 2025
Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Introduction: Round atrophic macular scars with a hyperpigmented rim in an otherwise healthy child are characteristic for prior ocular toxoplasmosis infection, the most common etiology of self-resolved retinitis in immunocompetent patients. However, a specific homozygous gene mutation (NM_148960: : c. 263T>A; p.
View Article and Find Full Text PDFDemography in Swiss paediatric uveitis: a retrospective cohort study.
J Ophthalmic Inflamm Infect
December 2024
Department of Ophthalmology, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 24, Zurich, 8091, Switzerland.
Introduction: Paediatric uveitis is a rare disease. It can affect any segment and have various etiologies, including infectious, autoimmune, and masquerade diseases. The pupose of this study is to analyse and present the demographic data in paediatric uveitis in a Swiss cohort.
View Article and Find Full Text PDFClinical characteristics and optical coherence tomography features of ocular toxoplasmosis inHIV-positive patients: report 1.
Br J Ophthalmol
November 2024
Department of Vitreoretina and Uveitis Services, LV Prasad Eye Institute GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India.
Purpose: This study aimed to identify the various clinical characteristics and ocular imaging features of ocular toxoplasmosis (OT) in HIV patients.
Methods: Observational retrospective study of 52 eyes of 38 HIV patients with OT.
Results: 68% of patients were male.
Coinfection of cerebral toxoplasmosis and neurosyphilis as the first manifestation of AIDS.
BMJ Case Rep
September 2024
Department of Medicine, Division of Infectious Disease, Rutgers New Jersey Medical School, Newark, New Jersey, USA
Article Synopsis
- - A 30-something man with newly diagnosed HIV (CD4 count of 292) showed symptoms like headaches and weakness in limbs, alongside a history of skin rashes that had resolved on their own.
- - Imaging tests (CT and MRI) revealed significant brain swelling and two enhancing masses, indicating severe issues possibly related to both cerebral toxoplasmosis and neurosyphilis.
- - The patient received treatment with trimethoprim/sulfamethoxazole and intravenous penicillin G, leading to a full resolution of his symptoms.
Coinfection Suspicion is Imperative in Immunosuppressed Patients with Suspected Infectious Uveitis and Inadequate Treatment Response: A Case Report.
Ocul Immunol Inflamm
December 2024
Neuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
Background: To report a case of coinfection of (Tg) and (EBV) in a diabetic patient with rheumatoid arthritis and immunosuppressive biological therapy.
Case Presentation: A 70-year-old female with a history of rheumatoid arthritis on therapy with corticosteroids, methotrexate, and abatacept presented bilateral granulomatous panuveitis associated with retinal necrosis and macular involvement. A diagnostic vitrectomy detected Tg and EBV.
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