Smoke condensates derived from three cigarette types of identical blend to which 0, 1 and 3% cocoa powder was added to the filler were assayed on mice by chronic dermal application (skin painting). For each cigarette type, three condensate doses were applied: 60, 90 and 125 mg dry condensate/mouse/week. The results obtained in this study do not provide evidence that the biological activity of the condensates, as indicated by the occurrence of non-tumorous and tumorous lesions, is enhanced by the addition of cocoa.
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Article Synopsis
- A systematic study was conducted to evaluate the cytotoxicity of conventional cigarettes compared to e-cigarettes, focusing on their aerosol and smoke components.
- The research discovered that conventional cigarettes (CSC) were significantly more cytotoxic than e-cigarettes (EAC), with results showing EAC required at least 12 times higher concentrations to achieve similar effects on certain cell types.
- Among various flavors tested, Cola-flavored EAC was the most toxic, primarily due to its flavoring agents, while differences in cellular mechanisms were noted, with CSC producing higher reactive oxygen species (ROS) levels and inhibiting autophagy compared to EAC.
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