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Versatile Keratin Fibrous Adsorbents with Rapid-Response Shape-Memory Features for Sustainable Water Remediation.
Nano Lett
October 2024
Shanghai Frontiers Science Center of Advanced Textiles, Donghua University, Shanghai 201620, China.
Biodegradable shape-memory polymers derived from protein substrates are attractive alternatives with strong potential for valorization, although their reconstruction remains a challenge due to the poor processability and inherent instability. Herein, based on Maillard reaction and immobilization, a feather keratin fibrous adsorbent featuring dual-response shape-memory is fabricated by co-spinning with pullulan, heating, and air-assisted spraying ZIF-8-NH. Maillard reaction between the amino group of keratin and the carbonyl group of pullulan improves the mechanics and thermal performance of the adsorbent.
View Article and Find Full Text PDFCorrection: Polygenic effects on the risk of Alzheimer's disease in the Japanese population.
Alzheimers Res Ther
July 2024
Department of Molecular Genetics, Brain Research Institute, Niigata University, 1‑757 Asahimachi, Niigata, 951‑8585, Japan.
Polygenic effects on the risk of Alzheimer's disease in the Japanese population.
Alzheimers Res Ther
February 2024
Department of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata, 951-8585, Japan.
Background: Polygenic effects have been proposed to account for some disease phenotypes; these effects are calculated as a polygenic risk score (PRS). This score is correlated with Alzheimer's disease (AD)-related phenotypes, such as biomarker abnormalities and brain atrophy, and is associated with conversion from mild cognitive impairment (MCI) to AD. However, the AD PRS has been examined mainly in Europeans, and owing to differences in genetic structure and lifestyle, it is unclear whether the same relationships between the PRS and AD-related phenotypes exist in non-European populations.
View Article and Find Full Text PDFCannflavins A and B with Anti-Ferroptosis, Anti-Glycation, and Antioxidant Activities Protect Human Keratinocytes in a Cell Death Model with Erastin and Reactive Carbonyl Species.
Nutrients
October 2023
Bioactive Botanical Research Laboratory, Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
Article Synopsis
- The study investigates the effects of reactive carbonyl species (RCSs) on ferroptosis, a specific type of cell death, in human skin cells (HaCaT).
- Researchers used various bioassays and proteomics to assess the cytotoxicity of RCSs alongside erastin, a known ferroptosis inducer, while also evaluating dietary flavonoids, cannflavins A and B, for their protective effects.
- Findings indicate that cannflavins A and B significantly improved cell viability and reduced lipid peroxidation in response to RCSs and erastin, suggesting their potential as dietary treatments for aging-related skin issues.
Clinical manifestations of human leptospirosis: bacteria matter.
Front Cell Infect Microbiol
November 2023
Unité Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Université de La Réunion, CNRS 9192, INSERM 1187, IRD 249, La Réunion, France.
Introduction: A high incidence of human leptospirosis is recorded on Mayotte, an oceanic island located in southwestern Indian Ocean, but the severity of the disease appears relatively mild in terms of mortality rate and admission to the intensive care unit. It has been proposed that mild leptospirosis may result from a limited virulence of some of the occurring species to which the population is exposed.
Methods: Clinical and biological data of patients admitted to the Centre Hospitalier de Mayotte were collected and the infecting species were determined through molecular typing.
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