We describe a calorimetric assay for detection of voriconazole-resistant Aspergillus fumigatus within 8 h. Among 27 genetically distinct strains, all 21 resistant and all 6 susceptible strains were correctly identified by measurement of fungal heat production in the presence of voriconazole. This proof-of-concept study demonstrates the potential of microcalorimetry for rapid detection of azole resistance in A. fumigatus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811254 | PMC |
| http://dx.doi.org/10.1128/AAC.01379-13 | DOI Listing |
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