The authors evaluate the incidence of pulmonary embolism (PE) and its impact in patients who died in the cardiological department of the Institute of Clinical and Experimental Medicine during two five-year periods (1979-1983 and 1984-1988). These two periods are compared with the period 1974-1978 in the same department. The purpose was to assess the trend of fundamental findings (number of post-mortem examinations, number of PE, number of fatal PE, source of thrombosis in PE etc.). Based on the assembled findings it may be said that the number of p.m. examinations is increasing and thus also the number of PE. There was an obvious rise of the number of women with embolic, attacks in the cardiological department. Correct clinical diagnoses are equal in all periods.
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Int J Biol Sci
January 2025
Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dysregulated energy metabolism, particularly lipid metabolism disorders, has been identified as a key factor in the development of diabetic cardiomyopathy (DCM). Sirtuin 2 (SIRT2) is a deacetylase involved in the regulation of metabolism and cellular energy homeostasis, yet its role in the progression of DCM remains unclear. We observed significantly reduced SIRT2 expression in DCM model mice.
View Article and Find Full Text PDFJ Clin Med
December 2024
Pfizer S.L.U., 28108 Madrid, Spain.
Hereditary transthyretin amyloidosis (ATTRv) is an autosomal-dominant systemic disease, where amyloid fibrils accumulate especially in the peripheral and autonomic nervous systems and in the heart. The aim of the present work was to outline the follow-up and type of management received by asymptomatic carriers (ACs) and stage 1 ATTRv patients in Spain. A cross-sectional, non-interventional study was conducted throughout seven experienced hospitals in Spain.
View Article and Find Full Text PDFLife (Basel)
December 2024
Thoracic Surgery Unit, Careggi University Hospital, 50134 Florence, Italy.
Pectus excavatum (PE) can be associated with either congenital or acquired heart disease. This study highlights the importance of PE surgical repair in cases of severe chest depression on the heart in underlying cardiac diseases exacerbating cardiopulmonary impairment. From January 2023 to March 2024, four male patients underwent PE repair, having heart disease including pericarditis, mitral valve prolapse, ventricular fibrillation arrest and type 1 second-degree atrioventricular block.
View Article and Find Full Text PDFInt J Cardiol
December 2024
Department of Cardiology, Cardiovascular Institute, Thorax Center, Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Aims: (i) Investigate the prevalence of hypertrophic cardiomyopathy (HCM) in individuals with pathogenic/likely pathogenic (P/LP) gene variants detected through family cascade testing in relatives, and (ii) evaluate phenotypic progression in genotype-positive phenotype-negative (G+/P-) individuals during follow-up.
Results: From 2000 to 2023, 273 individuals underwent cardiologic evaluation following P/LP variant detection through family screening. Upon initial evaluation, HCM was diagnosed in 128 (47 %) individuals.
J Imaging
November 2024
Department of Radiology, Maternal-Child, Senological, Cardiological Radiology and Outpatient Ultrasound, University Hospital of Marche, 60126 Ancona, Italy.
Magnetic resonance (MR) defecography, including both static and dynamic phases, is frequently requested by gastroenterologists and colorectal surgeons for planning the treatment of obstructive defecation syndrome and pelvic organ prolapse. However, reports often lack key information needed to guide treatment strategies, making management challenging and, at times, controversial. It has been hypothesized that using structured radiology reports could reduce missing information.
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