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Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Keck School of Medicine of USC, Los Angeles, CA, USA.
Background: Research on biomarkers for Alzheimer's pathology has progressed rapidly. We summarize the evidence and make recommendations about biomarkers for future clinical use.
Method: Our interdisciplinary, international, multicultural group of experts in the Lancet Commission on dementia adopted a triangulation framework, prioritizing systematic reviews and meta-analyses and agreed on the best evidence for recommendations.
The Elusive Ternary Intermediates of Chiral Phosphoric Acids in Ion Pair Catalysis─Structures, Conformations, and Aggregation.
J Am Chem Soc
January 2025
Institute of Organic Chemistry, University Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.
In ion-pair catalysis, the last intermediate structures prior to the stereoselective transition states are of special importance for predictive models due to the high isomerization barrier between - and -substrate double bonds connecting ground and transition state energies. However, in prior experimental investigations of chiral phosphoric acids (CPA) solely the early intermediates could be investigated while the key intermediate remained elusive. In this study, the first experimental structural and conformational insights into ternary complexes with CPAs are presented using a special combination of low temperature and relaxation optimized N HSQC-NOESY NMR spectroscopy to enhance sensitivity.
View Article and Find Full Text PDFBibliometric Analysis of the Composition of Landmark Cerebral Venous Sinus Thrombosis Research.
Int J Cerebrovasc Dis Stroke
August 2024
Department of Neurology, Neurosurgery, & Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, United States.
Background: Cerebral Venous Sinus Thrombosis (CVST) is a relatively rare type of stroke, accounting for less than 3% of all stroke cases, and is associated with significant morbidity and mortality in young females. However, when promptly diagnosed and treated, it can have favorable outcomes. Several knowledge gaps remain regarding pathophysiology, diagnosis, and management of CVST, so critical assessment of past and present research could help close these gaps or establish targeted future research goals.
View Article and Find Full Text PDFRemote and Cross-Cultural Training of Research Assistants Abroad to Conduct Neuropsychological Tests: Lessons Learned.
Arch Clin Neuropsychol
January 2025
Departments of Neurology and Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.
There are no published guidelines regarding remotely training research assistants (RAs) to conduct neuropsychological tests. With technological advances allowing for increased international collaboration within the medical and research communities, challenges often arise from such partnerships, including linguistic, cultural, and physical barriers. A notable challenge for supervising neuropsychologists in international projects is the physical distance from RAs, sites, and materials, making training/supervision of RAs and monitoring test data quite challenging.
View Article and Find Full Text PDFReactive oxygen species favors Varicellovirus bovinealpha 5 (BoAHV-5) replication in neural cells.
Mitochondrion
January 2025
Laboratorio de Virología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Campus Universitario, Tandil, Buenos Aires, Argentina; Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Campus Universitario, Tandil, Buenos Aires, Argentina. Electronic address:
Varicellovirus bovinealpha (BoAHV) 1 and 5 are closely related neurotropic alphaherpesviruses with distinct neuropathogenic potential. BoAHV-5 causes meningoencephalitis in calves whereas encephalitis by BoAHV-1 infection is sporadic. the mechanisms underlying the differences in tropism and clinical outcomes of the infections are not yet completely understood.
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