Induction of heat shock proteins (HSP's) synthesis in human lymphocytes in vitro was studied using 1D- and 2D-polyacrylamide gel electrophoresis. High resolution of the O'Farrell's procedure revealed the existence of several isoforms of HSP70. The same major HSP's (70 kDa and 88 kDa) were found in rabbit lymphocytes in vivo under whole body hyperthermia. Freshly isolated lymphocytes seem to offer a new approach to the investigation of HSP synthesis induction in mammals under whole body hyperthermia.
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