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Intracellular Retention of Estradiol is Mediated by GRAM Domain-Containing Protein ASTER-B in Breast Cancer Cells.
Mol Cancer Res
January 2025
The University of Texas Southwestern Medical Center, Dallas, TX, United States.
Elevated blood levels of estrogens are associated with poor prognosis in estrogen receptor-positive (ER+) breast cancers, but the relationship between circulating blood hormone levels and intracellular hormone concentrations are not well characterized. We observed that MCF-7 cells treated acutely with 17β-estradiol (E2) retain a substantial amount of the hormone even upon removal of the hormone from the culture medium. Moreover, global patterns of E2-dependent gene expression are sustained for hours after acute E2 treatment and hormone removal.
View Article and Find Full Text PDFQSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction.
Nat Commun
September 2024
Centre for Endocrinology, John Vane Science Centre, Queen Mary University of London, Charterhouse Square, London, UK.
Article Synopsis
- * QSOX2 is crucial for the proper functioning of Growth hormone by facilitating the transit of a signaling protein (STAT5B) into the nucleus, and its deficiency leads to impaired cellular processes and multi-system issues.
- * The findings suggest that using recombinant insulin-like growth factor-1 could help address the problems caused by the defective QSOX2 gene, potentially improving organ-specific health outcomes.
Hormonal orchestra: mastering mitochondria's role in health and disease.
Endocrine
December 2024
Universite Claude Bernard Lyon-1, CNRS, ISA-UMR 5280, Villeurbanne, France.
Article Synopsis
- Mitochondria play a crucial role in various cellular processes, influencing stress responses, immune functions, metabolism, and cell death through mechanisms like fission, fusion, and mitophagy.
- The interaction between hormones and mitochondria affects ATP production and impacts mitochondrial composition, which is vital in processes such as apoptosis and steroid hormone biosynthesis.
- Disruptions in mitochondrial function can lead to serious health issues, including neurodegenerative diseases and cancers, while hormones can enhance mitochondrial biogenesis and offer potential therapeutic applications.
Follicular Atresia in Buffalo: Cocaine- and Amphetamine-Regulated Transcript (CART) and the Underlying Mechanisms.
Animals (Basel)
July 2024
Guangxi Key Laboratory of Buffalo Genetics, Reproduction and Breeding, Guangxi Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning 530001, China.
Article Synopsis
- Atresia in ovarian follicles is controlled by hormone-induced apoptosis, particularly involving granulosa cell (GC) death through various signaling pathways.
- The research focused on the role of Cocaine- and amphetamine-regulated transcript (CART) in promoting GC apoptosis and its effects on the AKT/GSK3β/β-catenin signaling pathways in buffalo.
- Findings showed that CART treatment reduced GC viability, increased apoptosis, and altered gene expression tied to these pathways, suggesting that CART plays a critical role in follicular atresia in buffalo.
NCLX controls hepatic mitochondrial Ca extrusion and couples hormone-mediated mitochondrial Ca oscillations with gluconeogenesis.
Mol Metab
September 2024
Department of Physiology and Cell Biology, Ben Gurion University, Beer-Sheva 8410501, Israel. Electronic address:
Objective: Hepatic Ca signaling has been identified as a crucial key factor in driving gluconeogenesis. The involvement of mitochondria in hormone-induced Ca signaling and their contribution to metabolic activity remain, however, poorly understood. Moreover, the molecular mechanism governing the mitochondrial Ca efflux signaling remains unresolved.
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