Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bjps.2013.07.028 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Single-incision cochlear implantation and hearing evaluation in piglets and minipigs.
Hear Res
December 2022
Department of Otorhinolaryngology - Head and Neck Surgery, Vienna General Hospital, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address:
Objectives: Various animal models have been established and applied in hearing research. In the exploration of novel cochlear implant developments, mainly rodents have been used. Despite their important contribution to the understanding of auditory function, translation of experimental observations from rodents to humans is limited due to the size differences and genetic variability.
View Article and Find Full Text PDFLocal Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials.
Pharmaceuticals (Basel)
September 2022
Translational Hearing Center, Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA.
Hearing loss negatively impacts the well-being of millions of people worldwide. Systemic delivery of ototherapeutics has limited efficacy due to severe systemic side effects and the presence of the blood-labyrinth barrier that selectively limits or enables transfer of molecules between plasma and inner ear tissues and fluids. Local drug delivery into the middle and inner ear would be preferable for many newly emerging classes of drugs.
View Article and Find Full Text PDF[Reconstruction of complex tissue defects in temporal region: report of 3 cases].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
May 2021
Institute of Otolaryngology, Chinese PLA General Hospital, Beijing 100853, China National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China.
To discuss the techniques and repairing methods of various degree of compound tissue defects in the auriculotemporal region. Retrospective analysis was conducted on three cases of different repairing methods for huge compound tissue defects in different degrees in the auriculotemporal region after the resection of the malignant tumor or sinus tract due to repeated infection in our hospital. Following total removal of the tumors or sinus tract in all patients, we applied retroauricular lingual flap transfer repairing, latissimus dorsi flap free transfer repairing and vascular anastomosis, scalp tissue expansion in stage Ⅰ, then repairing the lesion with expanded scalp and filling the huge mastoid cavity with abdominal fat in stage Ⅱ, respectively, according to the characteristics of compound tissue defects in the auriculotemporal region.
View Article and Find Full Text PDFCochlear Implantation in the Guinea Pig.
J Vis Exp
June 2018
Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna.
Cochlear implants are highly efficient devices that can restore hearing in subjects with profound hearing loss. Due to improved speech perception outcomes, candidacy criteria have been expanded over the last few decades. This includes patients with substantial residual hearing that benefit from electrical and acoustical stimulation of the same ear, which makes hearing preservation during cochlear implantation an important issue.
View Article and Find Full Text PDFRASopathic comedone-like or cystic lesions induced by vemurafenib: a model of skin lesions similar but not identical to those induced by dioxins MADISH.
J Eur Acad Dermatol Venereol
August 2018
Department of Pharmacology and Toxicology, University of Geneva, Geneva, Switzerland.
Background: Patients treated with vemurafenib for metastatic melanoma often develop skin lesions similar to those observed after exposure to dioxin-like compounds. We previously called these lesions MADISH (metabolizing acquired dioxin-induced skin hamartoma) when analysing a case of acute dioxin poisoning.
Objective: We performed a clinical trial aimed at comparing the skin lesions observed under vemurafenib treatment with MADISH in order to bring to light a possible crosstalk between vemurafenib and dioxin pathways.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!