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Secondary Syphilis Presenting With an Interstitial Granuloma Annulare-Like Histopathologic Pattern: A Report of 2 Cases.
Am J Dermatopathol
February 2025
Bioptic Laboratory, Ltd, Pilsen, Czech Republic.
Syphilis, known as "the great mimicker," is caused by the spirochete Treponema pallidum and is characterized by a diverse array of clinical and histopathologic presentations. In secondary cutaneous syphilis, the most consistent morphological features include a superficial and deep perivascular infiltrate containing plasma cells, varying degrees of endothelial swelling, irregular acanthosis, elongation of rete ridges, a vacuolated pattern, and the presence of plasma cells. Although serologic tests are essential for definitive diagnosis, spirochetes can sometimes be directly identified in silver-stained tissue slides or through immunohistochemistry.
View Article and Find Full Text PDFRecurrent aseptic abscesses resulting in superficial pyoderma gangrenosum-like ulcers in a patient with granulomatosis with polyangiitis.
Dermatol Online J
October 2024
Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Patients with granulomatosis with polyangiitis occasionally present with cutaneous manifestations, which are important clues for the early diagnosis. Although pyoderma gangrenosum-like ulcers are rarely observed, a unique case with unusual clinical features is presented herein. A 75-year-old woman with positive proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) repeatedly developed aseptic abscesses on the abdomen, buttock, lower legs, and forearms.
View Article and Find Full Text PDFLeishmaniasis masquerading as pyoderma gangrenosum in a non-endemic area: A case report.
Australas J Dermatol
November 2024
Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.
Pyoderma gangrenosum (PG) can be difficult to diagnose, leading to diagnostic delay which affects patient outcomes and increases health care utilization. Among different scenarios of diagnostic delay, atypical infections can mimic PG. Here, we present a case of extensive cutaneous leishmaniasis initially misdiagnosed as the superficial granulomatous variant of PG and describe diagnostic clues to aid in differentiation.
View Article and Find Full Text PDFThe histologic diagnosis and the management of cystic neutrophilic granulomatous mastitis: a case report.
J Med Case Rep
November 2024
Pathology and Cytology Department B, Salah Azeiz Institute, Bab Saadoune, Tunis, Tunisia.
Article Synopsis
- * A case study involved a 44-year-old woman with a painful breast mass, ultrasound showed lesions and abscess formation, leading to a biopsy that confirmed inflammatory changes without cancer.
- * The patient was treated with steroids and antibiotics, underwent surgery, and improved clinically, highlighting the need for better understanding of this condition and its optimal treatment options.
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