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Oncocytic Carcinoma Ex-Pleomorphic Adenoma of the Lacrimal Gland.
Ophthalmic Plast Reconstr Surg
January 2025
Adnexal Service, Moorfields Eye Hospital, London EC1V 2PD, United Kingdom.
Oncocytic carcinoma is a rare malignant neoplasm of oncocytic cells, such cells being characterized by abundant granular eosinophilic cytoplasm, invasive growth, and pronounced cellular pleomorphism. It may arise de novo, or through malignant transformation of a pre-existing benign oncocytoma. Oncocytic carcinoma most commonly occurs in the salivary glands, with rare involvement of the ocular adnexa where it mainly affects caruncle, conjunctiva, and lacrimal sac, and only very arises in the lacrimal gland.
View Article and Find Full Text PDFOncocytic lesions of the ocular adnexa: A review of the histopathology with a brief discussion of the pathogenesis.
Saudi J Ophthalmol
April 2022
Eye Associates of New Mexico, Albuquerque, NM, USA.
Oncocytic lesions may be metaplastic, hyperplastic, or neoplastic and occur in a variety of tissues, including those of the ocular adnexa. Oncocytes are enlarged epithelial cells with abundant eosinophilic granules in the cytoplasm, which represent large mitochondria with distorted cristae. The causes of oncocytic lesions remain uncertain, although in some sites such as the lacrimal sac, chronic inflammation may be a factor.
View Article and Find Full Text PDFRecurrent Oncocytoma of the Lacrimal Sac.
Case Rep Pathol
February 2022
Department of Oculoplastic Surgery, King Khaled Eye Specialist Hospital, Al Urubah Road, Umm Al Hamam Al Gharbi, Riyadh 11462, Saudi Arabia.
Oncocytoma of the lacrimal sac is an extremely rare tumor. In this report, we present the case of an 82-year-old woman who presented with swelling in the region of the lacrimal sac. Systemic examination and ophthalmic examination of both eyes were unremarkable.
View Article and Find Full Text PDFClinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn.
Graefes Arch Clin Exp Ophthalmol
April 2022
Department of Ophthalmology, University Hospital Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Germany.
Purpose: The lacrimal caruncle is composed of numerous structures including different glands as well as hair follicles. Accordingly, the spectrum of benign and malignant lesions is broad, and the clinical diagnosis is often challenging. Here we systematically analyzed excised caruncular tumors over the past 22 years with special emphasis on the clinico-pathological correlation to provide a guidance for clinicians.
View Article and Find Full Text PDFUnusual Case of a Caruncular Oncocytoma.
Am J Dermatopathol
December 2021
Dermatology Section, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA.
Article Synopsis
- A case study details a 68-year-old man with a 1mm papule, experiencing discomfort, which was diagnosed through biopsy revealing unique cell characteristics and the need to rule out a potentially similar but malignant condition.
- Complete surgical excision is the preferred treatment, emphasizing the importance of understanding the rare occurrence of ocular oncocytomas for dermatologists and pathologists.
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