Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijcard.2013.07.165 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
fate of Chikungunya virus replication organelles.
J Virol
July 2024
Centre de Biologie Structurale (CBS), Université de Montpellier, CNRS, INSERM, Montpellier, France.
Chikungunya virus (CHIKV) is a mosquito-borne pathogen responsible for an acute musculoskeletal disease in humans. Replication of the viral RNA genome occurs in specialized membranous replication organelles (ROs) or spherules, which contain the viral replication complex. Initially generated by RNA synthesis-associated plasma membrane deformation, alphavirus ROs are generally rapidly endocytosed to produce type I cytopathic vacuoles (CPV-I), from which nascent RNAs are extruded for cytoplasmic translation.
View Article and Find Full Text PDFPharmaceutical Considerations and Metabolic Fate of Parenteral Lipid Nanoparticle Dosage Forms.
J Pharm Sci
August 2024
Harvard Medical School, Boston, MA, USA.
The physical stability of parenteral dispersions for delivery of drugs to patients is of particular clinical importance, given their general overall superior bioavailability compared to other routes of administration. Although official pharmacopeial methods for lipid injectable emulsions have been established for triglyceride oil-in-water dispersions (i.e.
View Article and Find Full Text PDFBiphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification.
Proc Natl Acad Sci U S A
January 2018
Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109
Article Synopsis
- - The study explores how glial cell line-derived neurotrophic factor (GDNF) influences the development of taste-related sensory neurons in mice, particularly focusing on the geniculate ganglion (GG).
- - GDNF functions biphasically: initially amplifying the expression of the chemosensory marker Phox2b during early development and later playing a role in identifying mechanoreceptors in adulthood.
- - The research indicates that the Ret receptor is crucial for establishing chemosensory neuron identity but not for maintaining it, highlighting distinct developmental phases in the taste system.
The fate of large-diameter Dacron® vascular grafts in surgical practice: are we really satisfied?
Int J Cardiol
October 2013
Department of Cardiac Surgery, University Hospital UZ Leuven, Belgium. Electronic address:
Neural crest origin of olfactory ensheathing glia.
Proc Natl Acad Sci U S A
December 2010
Department of Physiology, University of Cambridge, Cambridge CB2 3DY, United Kingdom.
Olfactory ensheathing cells (OECs) are a unique class of glial cells with exceptional translational potential because of their ability to support axon regeneration in the central nervous system. Although OECs are similar in many ways to immature and nonmyelinating Schwann cells, and can myelinate large-diameter axons indistinguishably from myelination by Schwann cells, current dogma holds that OECs arise from the olfactory epithelium. Here, using fate-mapping techniques in chicken embryos and genetic lineage tracing in mice, we show that OECs in fact originate from the neural crest and hence share a common developmental heritage with Schwann cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!