Protein complexes: breaking up is hard to do well.

Structure

Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Published: August 2013

Mass spectrometry of protein assemblies reveals size and stoichiometry. In this issue of Structure, Hall and colleagues demonstrate that gas-phase dissociations can recapitulate solution structure for complexes with few intersubunit salt bridges, high charge density, inflexible subunits, or small intersubunit interfaces.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775335PMC
http://dx.doi.org/10.1016/j.str.2013.07.013DOI Listing

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