AI Article Synopsis
- Forensic DNA typing has evolved through three generations, with short tandem repeats (STR) currently being a standard tool for identification.
- Recent advancements in genomic research have led to the identification of polymorphism markers such as single nucleotide polymorphisms (SNP) and Insertion/Deletion (InDel) markers, which show promise in forensic and medical biology.
- The paper reviews the historical development of InDel research, highlights their application in forensic biology and anthropology, and discusses future research directions and challenges that need to be addressed.
Article Abstract
As forensic DNA typing experienced three generations of genetic marker researching stage, short tandem repeat (STR) has been widely used in forensic identification as a mature tool. Further exploration of the human genome led to the discovery of polymorphism markers of single nucleotide polymorphism (SNP) and Insertion/Deletion (InDel). InDel, which combines the desirable characteristics of previous genetic markers as a new type of genetic marker, has got extensive concern in fields like medical molecular biology and forensic biology. This paper generally reviews the history of research and the corresponding results of InDel along the line of time axis as well as the different aims of these research focusing on the progress in the multiple amplification system with several InDel as the genetic marker (autosomal or X chromosome) in forensic biology and anthropology. Finally, the direction of research in this field and the problems to be solved have been put forward.
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