The use of Ag as a tool for studying biological distribution of silver-based antimicrobials.

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Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, 510 S. Kingshighway Blvd, St. Louis, MO 63110. ; Tel: 314-362-0284; Tel: 314-367-5537; Tel: 314-362-8154.

Published: June 2013

Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [Ag]SCC1 and investigated in biodistribution studies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733397PMC
http://dx.doi.org/10.1039/C3MD00082FDOI Listing

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