pH-Switchable ampholytic supramolecular copolymers.

Angew Chem Int Ed Engl

Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Münster (Germany) http://www.besenius-group.com; CeNTech, Münster (Germany).

Published: September 2013

AI Article Synopsis

  • β-sheet-encoded dendritic peptide amphiphiles can form supramolecular copolymers when mixed in equal parts.
  • These materials are specifically designed to undergo polymerization that can be activated or deactivated based on pH changes.
  • The self-assembly process starts at a pH level found in the human body and can be halted by adjusting the pH up or down.

Article Abstract

β-sheet-encoded anionic and cationic dendritic peptide amphiphiles form supramolecular copolymers when self-assembled in a 1:1 feed ratio of the monomers. These ampholytic materials have been designed for on-off polymerization in response to pH triggers. The cooperative supramolecular self-assembly process is switched on at a physiologically relevant pH value and can be switched off by increasing or decreasing the pH value.

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http://dx.doi.org/10.1002/anie.201303810DOI Listing

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