We report the first outbreak of carbapenem-resistant NDM-1-producing Acinetobacter baumannii in Europe, in a French intensive-care unit in January to May 2013. The index patient was transferred from Algeria and led to the infection/colonisation of five additional patients. Concurrently, another imported case from Algeria was identified. The seven isolates were genetically indistinguishable, belonging to ST85. The bla(NDM-1) carbapenemase gene was part of the chromosomally located composite transposon Tn125. This report underscores the growing concern about the spread of NDM-1-producing A. baumannii in Europe.
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http://dx.doi.org/10.2807/1560-7917.es2013.18.31.20547 | DOI Listing |
Microbiol Spectr
December 2024
Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.
Unlabelled: Carbapenem-resistant spp. pose a significant challenge in clinical settings due to limited treatment options for nosocomial infections. Carbapenem-hydrolyzing class D beta-lactamases are the primary cause for carbapenem resistance, while metallo-beta-lactamases (MBLs) New Delhi metallo beta-lactamase (NDM) and imipenemase (IMP) also contribute.
View Article and Find Full Text PDFmSphere
June 2024
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Unlabelled: This study aimed to characterize carbapenem-resistant (CRAB) isolates from Jiangxi patients using whole-genome sequencing (WGS). We subjected 100 clinical CRAB strains isolated from the three local largest teaching hospitals to WGS and antimicrobial susceptibility testing. Molecular epidemiology was investigated using multilocus sequence typing, core genome multilocus typing, core genome single-nucleotide polymorphism phylogeny, and pulsed-field gel electrophoresis.
View Article and Find Full Text PDFJ Glob Antimicrob Resist
September 2024
Department of Microbiology and Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea. Electronic address:
Microbiol Resour Announc
November 2023
Department of Biotechnology, School of Life Sciences, Pondicherry University, Pondicherry, India.
Among the species within complex, has not been frequently isolated from clinical settings, unlike , which is an important nosocomial pathogen. We report the genomic sequences of strains (PKAL1732 and 1828C) harboring multiple-resistance determinants including metallo-β-lactamase ( ) isolated from immunocompromised patients admitted to a referral hospital in India.
View Article and Find Full Text PDFJ Infect Chemother
December 2023
Division of Infection Control and Prevention, Department of Medical safety management, Kindai University Hospital, 377-2, Ohno-Higashi, OsakaSayama, Osaka, 589-8511, Japan.
New Delhi metallo-β-lactamase (NDM)-producing gram-negative rods, including Acinetobacter species, are a global problem but have rarely been isolated in Japan. To our knowledge, this is the first study to isolate an NDM-1-producing Acinetobacter soli strain, KUH106, in Japan. We analyzed this strain using next-generation sequencing to examine the plasmid carrying NDM-1.
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