AI Article Synopsis
- Genetic studies reveal that aortic dissection is influenced by multiple genes, indicating it is a multi-gene disorder.
- Researchers have identified specific genes linked to the development of aortic dissection using microarray screenings and testing for gene mutations.
- The findings suggest that genetic predispositions and changes play a significant role in the pathogenesis and natural history of aortic dissection.
Article Abstract
Genetic study can provide important insight into the etiology of aortic dissection. To explore the pathogenesis and natural history of aortic dissection, a number of genes have been identified through microarray chip screening and undergone testing of polymorphisms to find mutations strongly associated with the disease. The results suggested aortic dissection to be a multi-gene disorder. Multiple genes probably work together to promote its development. Several diseases with a genetic predisposition are closely connected with aortic dissection, which also implied a role of genetic changes and malfunction in this disease.
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| http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2013.04.012 | DOI Listing |
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