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Light-inducible activation of target mRNA translation in mammalian cells. | LitMetric
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Light-inducible activation of target mRNA translation in mammalian cells.

Jicong Cao Manish Arha Chaitanya Sudrik Lukasz J Bugaj David V Schaffer Ravi S Kane

Chem Commun (Camb)

Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

Published: September 2013

A genetically encoded optogenetic system was constructed that activates mRNA translation in mammalian cells in response to light. Blue light induces the reconstitution of an RNA binding domain and a translation initiation domain, thereby activating target mRNA translation downstream of the binding sites.

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 Source
http://dx.doi.org/10.1039/c3cc44866eDOI Listing

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