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Assessment of selected chlorinated and brominated flame retardants in human plasma samples among co-residing family members.
Environ Pollut
September 2019
Exposure and Biomonitoring Division, Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Ontario, Canada. Electronic address:
Three hexachloronorbornene-based flame retardants and five polybrominated diphenyl ethers (PBDEs) were measured in 414 human plasma samples, (169 from children, 167 from mothers, and 78 from fathers), collected from 200 families between 2014 and 2016. The median concentration of ∑PBDEs (sum of BDE-47, -99, -100, -153 and -183) was 13.2 ng/g lipid for child, 9.
View Article and Find Full Text PDFAbdelouahab et al. respond to "Maternal PBDEs and thyroid hormones".
Am J Epidemiol
September 2013
Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec, Canada.
CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model.
Cell Death Dis
October 2012
Institut National de la Santé et de la Recherche Médicale (INSERM), U1009, 114 rue Edouard Vaillant, 94805 Villejuif, France.
The chemokine receptor CXCR4 favors the interaction of acute myeloid leukemia (AML) cells with their niche but the extent to which it participates in pathogenesis is unclear. Here, we show that CXCR4 expression at the surface of leukemic cells allowed distinguishing CXCR4 (high) from CXCR4(neg/low) AML patients. When high levels of CXCR4 are expressed at the surface of AML cells, blocking the receptor function with small molecule inhibitors could promote leukemic cell death and reduce NOD/Shi-scid/IL-2Rγ(null) (NOG) leukemia-initiating cells (LICs).
View Article and Find Full Text PDFEcosystem matters: fish consumption, mercury intake and exposure among fluvial lake fish-eaters.
Sci Total Environ
December 2008
CINBIOSE, Université du Québec à Montréal (UQAM), Montréal (Québec), Canada H3C 3P8.
Many studies use the number of fish meals as an estimate of Hg intake, although fish Hg concentrations, even within the same species, can greatly vary. Furthermore, most freshwater advisories only refer to local catch, while market fish advisories only focus on market fish, although both can contribute to Hg body burden. The present study, carried out in lakeside communities from 2 ecosystems in Quebec, Canada, sought to (i) estimate Hg intake from local freshwater sources, hunted waterfowl and market fish and seafood, and (ii) examine the relations between fish consumption, estimated Hg intake and biomarkers of exposure.
View Article and Find Full Text PDFFish intake and serum fatty acid profiles from freshwater fish.
Am J Clin Nutr
December 2006
CINBIOSE, Université du Québec à Montréal, Montréal, Canada.
Background: Although high mercury concentrations in fish diets raise an alarm, fish can also be a healthy choice because it is the primary source of n-3 fatty acids (FAs). However, little information is available on the contribution of freshwater fish to serum FA concentrations.
Objective: This study examined the FA pathway from fish to serum in 243 moderate consumers of freshwater fish.
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