AI Article Synopsis
- The study aimed to determine if B-type natriuretic peptide (BNP) levels at the start of continuous renal replacement therapy (CRRT) could predict mortality in acute kidney injury (AKI) patients.
- Among 149 enrolled patients, those who died had significantly higher median BNP levels (1812.5 pg/mL) compared to survivors (475.0 pg/mL), indicating a strong correlation with mortality risk.
- BNP levels above 1054 pg/mL were linked to a much higher mortality rate (76.6%) compared to those with lower levels (34.7%), suggesting that BNP can be a useful biomarker for assessing AKI prognosis during CRRT.
Article Abstract
Objectives: Acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT) is associated with poor outcome. Plasma B-type natriuretic peptide (BNP) is a biomarker related to fluid volume overload, and is elevated in AKI patients. The purpose of the study was to assess whether BNP levels at the time of starting CRRT could be used as a predictor of mortality in patients with AKI receiving CRRT.
Methods: We conducted a prospective observational cohort study enrolling 149 patients with AKI receiving CRRT. The primary outcome was mortality during CRRT.
Results: The median BNP level of 84 (56.3%) patients who expired was significantly higher than that of those who survived (1812.5 vs. 475.0 pg/mL; p = 0.01). Receiver operating characteristic curves demonstrated BNP levels as a predictor of mortality during CRRT with an area under the curve of 0.77 (p = 0.000), and the optimal threshold for BNP was 1054 pg/mL. Patients with BNP levels above 1054 pg/mL had a significantly higher mortality (76.6 vs. 34.7%; p = 0.01).
Conclusion: Elevated BNP level is associated with mortality in patients with AKI receiving CRRT.
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| http://dx.doi.org/10.3109/0886022X.2013.823870 | DOI Listing |
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