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Effectiveness and safety of traditional Chinese therapies intreating patients with amyotrophic lateral sclerosis: a protocol for systematic review and meta-analysis.
Front Neurol
December 2024
Department of Tuina and Rehabilitation Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
Background: Amyotrophic lateral sclerosis (ALS) is a chronic, progressive disease that affects both upper and lower motor neurons. Some physicians have used traditional Chinese therapies (TCT) to treat ALS. However, there has been no systematic review or meta-analysis to evaluate the effectiveness and safety of TCT interventions.
View Article and Find Full Text PDFAn integrative review of the effects of high-intensity interval training on the autonomic nervous system.
Sports Med Health Sci
March 2025
Laboratory of Experimental Neurosciences, University of South Santa Catarina (UNISUL), Avenida Pedra Branca n 25, 88137-900, Palhoça, Santa Catarina, Brazil.
High-Intensity Interval Training (HIIT) has gained prominence as a time-efficient and effective exercise modality to improve cardiovascular (CV) fitness, metabolic health, and physical performance. Therefore, our aim was to synthesize current clinical research on the effects of HIIT on the Autonomic Nervous System. We conducted the search for studies in the Directory of Open Access Journals, Embase, Virtual Health Library, Pubmed, and Scielo databases, in January of 2024.
View Article and Find Full Text PDFA study protocol to develop virtual reality software in the care management of patients in intensive care.
Nurs Crit Care
January 2025
Teaching in Nursing Department, Faculty of Nursing, Akdeniz University, Antalya, Turkey.
Background: The use of virtual reality is increasing in nursing to ensure patient safety and to improve the quality of care in the education of nurses.
Aim: To develop a virtual reality software for intensive care patient care management and to investigate the effect of this software on novice intensive care nurses.
Study Design: This study protocol contains a randomized controlled experimental design research.
Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease.
Alzheimers Res Ther
January 2025
Department of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco 15, Turin, 10126, Italy.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with both genetic and environmental factors contributing to its pathogenesis. While early-onset AD has well-established genetic determinants, the genetic basis for late-onset AD remains less clear. This study investigates a large Italian family with late-onset autosomal dominant AD, identifying a novel rare missense variant in GRIN2C gene associated with the disease, and evaluates the functional impact of this variant.
View Article and Find Full Text PDFEvaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons.
BMC Med Genomics
January 2025
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
Amyotrophic lateral sclerosis (ALS) lacks a specific biomarker, but is defined by relatively selective toxicity to motor neurons (MN). As others have highlighted, this offers an opportunity to develop a sensitive and specific biomarker based on detection of DNA released from dying MN within accessible biofluids. Here we have performed whole genome bisulfite sequencing (WGBS) of iPSC-derived MN from neurologically normal individuals.
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