AI Article Synopsis
- 3-Alkyloxy and 3-amino phthalic acid derivatives were discovered to inhibit metallo-β-lactamase enzymes.
- Among these, 3-amino phthalic acid derivatives were especially effective against the IMP-1 variant and enhanced the effects of the antibiotic biapenem (BIPM).
- Notably, the 4'-hydroxy-piperidine derivative exhibited significant IMP-1 inhibitory activity and worked well in combination with multiple antibiotics.
Article Abstract
3-Alkyloxy and 3-amino phthalic acid derivatives were found to have metallo-β-lactamase inhibitory activity. Among them, 3-amino phthalic acid derivatives showed both potent activity against metallo-β-lactamase, IMP-1 inhibitory activity and a strong combination effect with biapenem (BIPM), carbapenem antibiotic. In particular, the 4'-hydroxy-piperidine derivative showed strong IMP-1 inhibitory activity and a combination effect with various antibiotics.
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| http://dx.doi.org/10.1016/j.bmc.2013.07.006 | DOI Listing |
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