AI Article Synopsis
- - DNA mismatch repair (MMR) plays a critical role in fixing DNA damage caused by ionizing radiation (IR) and chemotherapy drugs like iododeoxyuridine (IUdR), which can enhance the effects of IR.
- - Researchers created probabilistic cell cycle models to study how IUdR and IR, individually and together, affect MMR processes in both MMR-proficient and deficient cells over two cell cycles.
- - The study found that the duration of G1 and G2/M phases in the cell cycle varies after treatment, providing insights that could help improve cancer therapies, particularly for cancers that are MMR-deficient.
Article Abstract
DNA mismatch repair (MMR) is involved in processing DNA damage following treatment with ionising radiation (IR) and various classes of chemotherapy drugs including iododeoxyuridine (IUdR), a known radiosensitiser. In this study, the authors have developed asynchronous probabilistic cell cycle models to assess the isolated effects of IUdR and IR and the combined effects of IUdR + IR treatments on MMR damage processing. The authors used both synchronous and asynchronous MMR-proficient/MMR-deficient cell populations and followed treated cells for up to two cell cycle times. They have observed and quantified differential cell cycle responses to MMR damage processing following IR and IUdR + IR treatments, principally in the duration of both G1 and G2/M cell cycle phases. The models presented in this work form the foundation for the development of an approach to maximise the therapeutic index for IR and IUdR + IR treatments in MMR-deficient (damage tolerant) cancers.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884822 | PMC |
| http://dx.doi.org/10.1049/iet-syb.2012.0050 | DOI Listing |
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