A label-free kinase detection system was fabricated by the adsorption of gold nanoparticles functionalized with kinase inhibitor onto AlGaN/GaN high electron mobility transistors (HEMTs). The HEMTs were operated near threshold voltage due to the greatest sensitivity in this operational region. The Au NP/HEMT biosensor system electrically detected 1 pM SRC kinase in ionic solutions. These results are pertinent to drug development applications associated with kinase sensing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716718 | PMC |
| http://dx.doi.org/10.1063/1.4812987 | DOI Listing |
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