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Design and characterization of a micro RNA-200c detecting Broccoli fluorescent light-up aptamer.
Chembiochem
January 2025
Ludwig-Maximilians-Universitat Munchen, Chemistry, Butenandstr. 5-13, 81377, Muenchen, GERMANY.
In the last decade the important role of small non-coding RNAs such as micro RNAs (miRs) in gene regulation in healthy and disease states became more and more evident. The miR-200-family of miRs has been shown to play a critical role in many diseases such as cancer and neurodegenerative disorders and could be potentially important for diagnosis and treatment. However, the size of miRs of about ~21-23nt provide challenges for their investigation.
View Article and Find Full Text PDFPhotochemical Stabilization of Self-Assembled Spherical Nucleic Acids.
Small
January 2025
Department of Chemistry, McGill University, 801, Sherbrooke St. West, Montreal, QC, H3A 0B8, Canada.
Oligonucleotide therapeutics, including antisense oligonucleotides and small interfering RNA, offer promising avenues for modulating the expression of disease-associated proteins. However, challenges such as nuclease degradation, poor cellular uptake, and unspecific targeting hinder their application. To overcome these obstacles, spherical nucleic acids have emerged as versatile tools for nucleic acid delivery in biomedical applications.
View Article and Find Full Text PDFAutoGP: An Intelligent Breeding Platform for Enhancing Maize Genomic Selection.
Plant Commun
January 2025
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China; Hubei Hongshan Laboratory, Hubei, China. Electronic address:
In the face of climate change and the growing global population, there is an urgent need to accelerate the development of high-yielding crop varieties. To this end, vast amounts of genotype-to-phenotype data have been collected, and many machine learning (ML) models have been developed to predict phenotype from a given genotype. However, the requirement for high densities of single-nucleotide polymorphisms (SNPs) and the labor-intensive collection of phenotypic data are hampering the use of these models to advance breeding.
View Article and Find Full Text PDFIn vivo GABA detection by single-pulse editing with one shot.
Magn Reson Med
January 2025
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Purpose: Two-shot γ-aminobutyric acid (GABA) difference editing techniques have been used widely to detect the GABA H4 resonance at 3.01 ppm. Here, we introduce a single-shot method for detecting the full GABA H2 resonance signal, which avoids contamination from the coedited M macromolecules.
View Article and Find Full Text PDFSingle-Cell RNA-Sequencing of Zebrafish Olfactory Epithelium Identifies Odor-Responsive Candidate Olfactory Receptors.
Genes Cells
January 2025
Laboratory for Systems Molecular Ethology, RIKEN Center for Brain Science, Saitama, Japan.
Single-cell RNA-sequencing (scRNA-seq) is a powerful method to comprehensively overlook gene expression profiles of individual cells in various tissues, providing fundamental datasets for classification of cell types and further functional analyses. Here we adopted scRNA-seq analysis for the zebrafish olfactory sensory neurons which respond to water-borne odorants and pheromones to elicit various behaviors crucial for survival and species preservation. Firstly, a single-cell dissociation procedure of the zebrafish olfactory rosettes was optimized by using cold-active protease, minimizing artifactual neuronal activation.
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