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Vascular and Osteological Morphology of Expanded Digit Tips Suggests Specialization in the Wandering Salamander (Aneides vagrans).
J Morphol
January 2025
Department of Biology, Gonzaga University, Spokane, Washington, USA.
For over a century researchers have marveled at the square-shaped toe tips of several species of climbing salamanders (genus Aneides), speculating about the function of large blood sinuses therein. Wandering salamanders (Aneides vagrans) have been reported to exhibit exquisite locomotor control while climbing, jumping, and gliding high (88 m) within the redwood canopy; however, a detailed investigation of their digital vascular system has yet to be conducted. Here, we describe the vascular and osteological structure of, and blood circulation through, the distal regions of the toes of A.
View Article and Find Full Text PDFOptogenetic stimulation of the "Zusanli" acupoint alleviates inflammatory pain through active Wnt/β-Catenin and MAPK signaling pathway in rats.
Heliyon
November 2024
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
Inflammatory pain, an important form of common pain, negatively influences the quality of life. Pathway-selective optogenetic control is a popular tool in neuronal function research; however, attempts to modulate rodent behavior using pathway-selective optogenetics remain unverified. We developed a methodology for pathway-selective optogenetics in rats, focusing on the delivery of recombinant adeno-associated virus (rAAV) containing channelrhodopsin-2 (ChR2) injected at the "Zusanli" acupoints to the dorsal root ganglia (DRG) and toes, which is a part of the complex neuron network.
View Article and Find Full Text PDFA Modular Framework for Task-Agnostic, Energy Shaping Control of Lower Limb Exoskeletons.
IEEE Trans Control Syst Technol
November 2024
Department of Robotics, University of Michigan, Ann Arbor, MI 48109, USA.
Article Synopsis
- Various lower-limb exoskeletons can assist movement for both able-bodied individuals and those with mild to moderate gait disorders, but a universal control system for all activities doesn’t exist.
- The paper introduces a new modular control framework that optimizes joint torques for any exoskeleton configuration in real-time during daily activities like walking, ascending stairs, or transitioning from sitting to standing.
- The study tested this framework on eight able-bodied users with different joint setups, finding that unilateral configurations significantly reduced muscle activation during tasks, while bilateral setups showed minimal effects likely due to weight and design limitations.
Blue Toe Syndrome in Behçet's Disease: A Case Report.
Am J Case Rep
June 2024
Department of General and Vascular Surgery, King Abdullah University Hospital (KAUH), Jordan University of Science and Technology (JUST), Irbid, Jordan.
BACKGROUND Vascular Behçet's disease (VBD) is a rare but potentially life-threatening subtype of Behçet's disease that is characterized by multisystemic vasculitis. It primarily affects males with ancestry traced back to regions along the ancient Silk Road. Both arteries and veins, regardless of size, may exhibit complications, including aneurysmal degeneration or occlusion.
View Article and Find Full Text PDFLow-intensity pulsed ultrasound for 'no-option' chronic/critical limb-threatening ischaemia in a patient with Buerger disease: a case report.
Eur Heart J Case Rep
June 2024
Department of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
Article Synopsis
- Buerger disease, also known as thromboangiitis obliterans, causes inflammation in small- and medium-sized arteries, leading to serious issues like chronic limb-threatening ischaemia (CLTI) and potential limb amputation, even with smoking cessation and exercise.
- A case study of a 72-year-old Japanese man with severe CLTI and renal issues showed improvement using low-intensity pulsed ultrasound (LIPUS) after conventional treatment failed.
- LIPUS is a promising non-invasive treatment that may enhance blood flow and reduce symptoms in peripheral arterial disease, potentially preventing major amputations.
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