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Towards a more desirable dry powder inhaler formulation: large spray-dried mannitol microspheres outperform small microspheres. | LitMetric

AI Article Synopsis

  • The study assessed the performance of a dry powder inhaler (DPI) using albuterol sulphate and spray dried mannitol carrier particles, focusing on how particle size impacts the inhaler's effectiveness.* -
  • Researchers characterized mannitol particles in several ways (like size and shape) and found that larger particles led to better drug delivery and reduced wastage compared to smaller ones.* -
  • The findings suggest that the physical characteristics of mannitol, more than its size or flow ability, play a crucial role in how well the albuterol is aerosolized for inhalation.*

Article Abstract

Purpose: To investigate, for the first time, the performance of a dry powder inhaler (DPI, Aerolizer(®)) in the case of a model drug (i.e. albuterol sulphate) formulated with spray dried mannitol carrier particles with homogeneous shape and solid-state form but different sizes.

Methods: Spray dried mannitol (SDM) particles were characterized in terms of size, surface area, morphology, water content, solid-state, density and electrostatic charge by a novel approach. DPI formulations composed of SDM and albuterol sulphate (AS) were prepared and evaluated in terms of drug content homogeneity and in vitro aerosolization performance.

Results: All SDM particles generated similar fine particle fractions of AS. Formulations consisting of larger SDM particles demonstrated better drug content homogeneity, reduced amounts of drug loss and reduced oropharyngeal deposition. Comparing different SDM products demonstrated that SDM powders with relatively poorer flowability, wider size distributions and higher charge density generated DPI formulations with poorer drug content homogeneity and deposited higher amount of drug on the inhaler, mouthpiece adaptor and throat. DPI formulation total desirability increased linearly with the mean diameter of SDM.

Conclusion: Particle shape and solid-state form of mannitol could dominate over carrier size, bulk density, flowability and charge in terms of determining the aerosolization behaviour of AS formulated with mannitol carrier, at least within the experimental protocols applied in the present study.

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Source
http://dx.doi.org/10.1007/s11095-013-1132-2DOI Listing

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