Figueroa-Ramosa et al. (2013) concluded that the combination of sedation withdrawal and mechanical ventilation withdrawal trial was feasible and well tolerated. The conclusion is not well supported because of the absence of a comparison to the uncombined protocol and due to evidence that the patients did not tolerate them particularly well.
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http://dx.doi.org/10.1016/j.iccn.2013.05.002 | DOI Listing |
J Am Coll Cardiol
December 2024
Division of Cardiology, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Background: There are no contemporary reports that highlight the national outcomes for children with congenital heart disease (CHD) undergoing ventricular assist device (VAD) implantation.
Objectives: This study sought to evaluate differences in VAD outcomes for children with CHD to those with non-CHD as well as those with univentricular CHD to those with biventricular CHD.
Methods: Data for CHD and non-CHD patients from the multicenter ACTION (Advanced Cardiac Therapies Improving Outcomes Network) undergoing VAD implantation from April 2018 to February 2023 were included.
Viruses
November 2024
Oxford Vaccine Group, Department of Pediatrics, University of Oxford, Oxford OX1 2JD, UK.
Respiratory syncytial virus (RSV) has been recognized as a highly important cause of morbidity and mortality among children and adults. A cross-sectional study at representative sites in Jordan was undertaken to provide an assessment of the epidemiology and health and economic burdens of RSV and influenza infections in Jordan amongst hospitalized children under 5 years old for the period between 15 November 2022 and 14 April 2023. This study involved 1000 patients with a mean age of 17.
View Article and Find Full Text PDFMicroorganisms
December 2024
Department of Infectious Disease, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea.
The risk factors and outcomes associated with persistent bacteremia are not well-defined. This retrospective cohort study analyzed 214 cases of bacteremia diagnosed between 2005 and 2022 at two university hospitals, focusing on the clinical and microbiologic characteristics and outcomes of persistent bacteremia. Persistent bacteremia, defined as the detection of for ≥5 days after the initial blood culture, occurred in 25.
View Article and Find Full Text PDFPathogens
December 2024
Pediatric Intensive Care Unit, The Second Hospital of Hebei Medical University, Shijiazhuang 050050, China.
This study aims to investigate the risk factors for infection and mortality associated with carbapenem-resistant (CRKP) in hospitalized children, with the goal of providing valuable insights for the prevention and treatment of these bacterial infections. A retrospective case-control study was conducted, including 153 cases of carbapenem-sensitive infection in children and 49 cases of CRKP infection. Among the CRKP cases, 40 children survived and nine died.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician Kulakov V.I., 117997 Moscow, Russia.
Despite the increasing number of placenta accreta spectrum (PAS) cases in recent years, its impact on neonatal outcomes and respiratory morbidity, as well as the underlying pathogenetic mechanism, has not yet been extensively studied. Moreover, no study has yet demonstrated the effectiveness of antenatal corticosteroid therapy (CT) for the prevention of respiratory distress syndrome (RDS) in newborns of mothers with PAS at the molecular level. In this regard, microRNA (miRNA) profiling by small RNA deep sequencing and quantitative real-time PCR was performed on 160 blood plasma samples from preterm infants (gestational age: 33-36 weeks) and their mothers who had been diagnosed with or without PAS depending on the timing of the antenatal RDS prophylaxis.
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