Adolescent "storm and stress" has been a focal yet controversial developmental framework for over a century. In the present article, we challenge the current perspective that storm and stress is neither ubiquitous nor inevitable but probable. Instead, we argue, storm and stress is a vestigial developmental framework, and we propose a more comprehensive approach to understanding adolescent-typical changes based on six premises: (1) The biological changes of adolescence are inevitable and ubiquitous; (2) adolescent biological changes drive various mechanisms of adolescent behavior; (3) adolescent biological changes are shaped by environmental influences; (4) individual differences in adolescent emotional-behavior changes are domain specific and vary in intensity; (5) there are individual differences in the age of onset and duration of periods of adolescent change; and (6) individual differences in the duration and intensity of transitions in emotional arousal are functionally modulated by burgeoning emotion regulation skills. We conclude with the more comprehensive 4T (typicality, transactions, temperament, and timing) approach and suggestions to guide adolescent research in the 21st century.
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Life (Basel)
January 2025
Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has profoundly impacted global health, with pneumonia emerging as a major complication in severe cases. The pathogenesis of COVID-19 is marked by the overproduction of reactive oxygen species (ROS) and an excessive inflammatory response, resulting in oxidative stress and significant tissue damage, particularly in the respiratory system. Antioxidants have garnered considerable attention for their potential role in managing COVID-19 pneumonia by mitigating oxidative stress and modulating immune responses.
View Article and Find Full Text PDFPsychol Trauma
January 2025
Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences.
Objective: Youth may develop posttraumatic stress disorder (PTSD) following a hurricane. Triaging of mental health services is crucial to effectively deliver trauma-focused interventions following natural disasters. Given the increased likelihood of hurricanes due to the current climate crisis, this study sought to examine the dose-response effect between hurricane-related stressors and PTSD, identify a cumulative stressor cutoff score based on the number of hurricane-related stressors experienced, and identify important individual hurricane-related stressors in explaining PTSD symptoms among youth.
View Article and Find Full Text PDFProteins
January 2025
Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, Virginia, USA.
Starch accumulation in plants provides carbon for nighttime use, for regrowth after periods of dormancy, and for times of stress. Both ɑ- and β-amylases (AMYs and BAMs, respectively) catalyze starch hydrolysis, but their functional roles are unclear. Moreover, the presence of catalytically inactive amylases that show starch excess phenotypes when deleted presents questions on how starch degradation is regulated.
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January 2025
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA.
We know more about the costs of chronic stress than the benefits of the acute stress response-an adaptive response that buffers organisms from life-threatening challenges. As yet, no primate study has empirically identified how the stress response adaptively affects evolutionary fitness. Here, we take advantage of a natural experiment-an El Niño drought-that produced unprecedented mortality for wild white-faced capuchins.
View Article and Find Full Text PDFCureus
December 2024
Biotechnology, Shri Venkateshwara University, Gajraula, IND.
Sepsis-associated acute kidney injury (S-AKI) is a critical complication that significantly contributes to the morbidity and mortality of sepsis patients. This narrative review explores the complex and multifactorial pathophysiology of S-AKI, which involves hemodynamic alterations, microcirculatory dysfunction, endothelial damage, inflammatory responses, oxidative stress, and direct tubular injury. Conventional perspectives linking S-AKI primarily to reduced renal blood flow are now being reconsidered, with growing insights highlighting the significance of microcirculatory dysfunction and endothelial activation as key contributors.
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