Binary choice tasks, such as 2-alternative forced choice, show a complex yet consistent pattern of sequential effects, whereby responses and response times depend on the detailed pattern of prior stimuli going back at least 5 trials. We show this pattern is well explained by simultaneous incremental learning of 2 simple statistics of the trial sequence: the base rate and the repetition rate. Both statistics are learned by the same basic associative mechanism, but they contribute different patterns of sequential effects because they entail different representations of the trial sequence. Subtler aspects of the data that are not explained by these 2 learning processes alone are explained by their interaction, via learning from joint error correction. Specifically, the cue-competition mechanism that has explained classic findings in animal learning (e.g., blocking) appears to operate on learning of sequence statistics. We also find that learning of the base rate and repetition rate are dissociated into response and stimulus processing, respectively, as indicated by event-related potentials, manipulations of stimulus discriminability, and reanalysis of past experiments that eliminated stimuli or prior responses. Thus, sequential effects in these tasks appear to be driven by learning the response base rate and the stimulus repetition rate. Connections are discussed between these findings and previous research attempting to separate stimulus- and response-based sequential effects, and research using sequential effects to determine mental representations. We conclude that sequential effects offer a powerful means for uncovering representations and learning mechanisms.
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Circ Res
January 2025
Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China (X.H., J.Z., C.X., R.C., P.J., X.J., P.H.).
Background: Cardiac ischemia/reperfusion disrupts plasma membrane integrity and induces various types of programmed cell death. The ESCRT (endosomal sorting complex required for transport) proteins, particularly AAA-ATPase Vps4a (vacuolar protein sorting 4a), play an essential role in the surveillance of membrane integrity. However, the role of ESCRT proteins in the context of cardiac injury remains unclear.
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
State Key Laboratory of Ophthalmology, Optometry and Visual Science, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Background: Developing carrier-free nanomedicines via self-assembly of two antitumor drug molecules is a potential strategy for enhancing the combination treatment of tumors. Similarly, conventional chemotherapy combined with photodynamic therapy may synergistically improve the antitumor effect while minimizing the adverse reactions associated with antitumor treatment. Hyaluronic acid (HA) can bind to overexpressed HA receptors on the tumor cell surface, increasing cell internalization and resulting in good tumor-targeting properties.
View Article and Find Full Text PDFAcademic examination retakes are significant challenges in health professions education. With rigorous clinical assessments and high-stakes examinations, many students struggle to meet academic requirements, resulting in retakes. The voices and experiences of such students have often been absent within the broader discussion of health professions education.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
Introduction: T-lymphopenia (TLP) is a frequently observed condition in cancer patients, often exacerbated by conventional chemo/radiotherapy, which impairs the efficacy of subsequent immune checkpoint blockade (ICB) therapy. This study aimed to understand the impact of TLP on ICB responsiveness and explore potential therapeutic strategies to enhance antitumor immunity.
Methods: To investigate ICB responsiveness depending on the severity of TLP, first, we established TLP mouse models that mimic clinically observed mild and severe TLP through thymectomy and anti-Thy1-induced peripheral T cell depletion.
JBI Evid Synth
January 2025
Office of Institutional Effectiveness, Touro University Nevada, Henderson, NV, USA.
Objective: The objective of this review is to evaluate the effect of cochlear implants on cognitive function in pediatric patients with hearing loss.
Introduction: Cognitive impairments have been reported in children with hearing loss. This is supported by the auditory scaffolding hypothesis, which describes sound as the basis for processing sequential information.
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