Easy as 1,2,3: Reaction of methyl carbamate, triethyl orthoformate, and readily available alkenes provides a highly practical preparation of protected aminocyclopropanes. The reaction proceeds with preferential cis addition to alkenes, and cleavage of the methyl carbamate gives the free aminocyclopropanes as their HI salts.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065353 | PMC |
| http://dx.doi.org/10.1002/anie.201304720 | DOI Listing |
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