AI Article Synopsis
- A new family of multifunctional scaffolds has been created using Bioglass® derived foams with biopolymer coatings.
- The polymer coatings serve as carriers for vancomycin, an antibiotic, allowing for rapid drug delivery and sustained release to enhance wound healing.
- The inclusion of vancomycin-loaded microgels improves the scaffolds' bioactivity by promoting the formation of HA crystals in simulated body fluid.
Article Abstract
A new family of multifunctional scaffolds, incorporating selected biopolymer coatings on basic Bioglass® derived foams has been developed. The polymer coatings were investigated as carrier of vancomycin which is a suitable drug to impart antibiotic function to the scaffolds. It has been proved that coating with PLGA (poly(lactic-co-glycolic acid)) with dispersed vancomycin-loaded microgels provides a rapid delivery of drug to give antibacterial effects at the wound site and a further sustained release to aid mid to long-term healing. Furthermore, the microgels also improved the bioactivity of the scaffolds by acting as nucleation sites for the formation of HA crystals in simulated body fluid.
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| http://dx.doi.org/10.1016/j.msec.2013.05.002 | DOI Listing |
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