We aimed to evaluate the expression and diagnostic value of five immunohistochemical markers (HBME-1, Galectin-3, CK19, CD56 and p63) in a very large series of unequivocal papillary thyroid carcinoma (PTC) cases, including both the classic (CPTC) and the follicular variant (FVPTC). We performed an immunohistochemical analysis on a tissue micro-array of 204 PTCs (98 CPTCs, 90 FVPTCs, and 16 other variants). HBME-1 was the most sensitive marker, staining 95.9% of CPTCs and 81.1% of FVPTCs. CD56, a marker whose expression is reduced or absent in thyroid carcinoma, revealed a negative, "malignant" profile in 93.9% of CPTCs and 73.3% of FVPTCs. Galectin-3, CK19 and p63 were positive in 64.7%, 45.6% and 6.9% of PTCs, respectively. The immunopanel consisting of HBME-1, CD56 and/or CK19 reached the highest sensitivity (95.6%). The co-expression of 2 or more proteins was observed in 88.2% of PTCs, with HBME-1 and CD56 being the most frequent positive association (79.4%). We report a new panel of antibodies consisting of HBME-1, CK19 and CD56 that was found to be highly sensitive for both CPTC and FVPTC. This panel could be recommended as a supplement to the morphological criteria in the diagnosis of difficult FVPTC cases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.prp.2013.06.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Role of CD56, HBME-1, and CK19 Immunohistochemical Markers in the differential Diagnosing of Thyroid Neoplasms.
Niger Med J
November 2024
Windsor University School of Medicine, Brightons Estate, Cayon, St. Kitts.
Article Synopsis
- The study investigates the role of Immunohistochemistry (IHC) markers (CD56, HBME-1, CK19) in diagnosing malignant thyroid neoplasms, highlighting the challenges of distinguishing between benign and malignant lesions using traditional histopathology.
- Out of 60 thyroid specimens analyzed, 68.33% were found malignant, with significant loss of CD56 expression in malignant cases and high specificity for CK19 in differentiating follicular neoplasms.
- The research underscores the importance of incorporating IHC markers to improve diagnostic accuracy for thyroid cancers, particularly in cases of follicular variant papillary thyroid carcinoma and follicular thyroid carcinoma.
Lipocalin-2 expression in papillary thyroid carcinoma and its association with clinicopathological characteristics.
Eur Arch Otorhinolaryngol
September 2024
Department of Nuclear Medicine, Kayseri City Training and Research Hospital, Kayseri, Turkey.
Purpose: The present study aimed to assess Lipocalin-2 (LCN2) expression in patients with papillary thyroid cancer (PTC) and to compare it with multinodular goitre (MNG). We also investigated the correlation between LCN2 expression and clinicopathologic characteristics.
Methods: This retrospective study included 63 surgically treated adult patients with papillary carcinoma and 65 adult patients with a MNG.
Two Cases of Adrenal Cysts Lined by Thyroid Follicular Epithelium: Addressing Cellular Origin and Malignancy Concerns.
JCEM Case Rep
April 2024
Department of Diagnostic Pathology, Kobe University Hospital, Kobe, 650-0017, Japan.
Adrenal cysts lined by thyroid follicular epithelium are rare, with only 14 reported cases of "ectopic thyroid tissue" to date. While the primary consideration for differential diagnosis is thyroid carcinoma metastasis, exclusion of metastases is determined based on the absence of a primary thyroid lesion, serological euthyroidism, lack of thyroglobulin elevation, and absence of epithelial atypia. Herein, we report 2 cases of adrenal cysts lined by thyroid follicular epithelium.
View Article and Find Full Text PDFEvaluation of the follicular patterned thyroid lesions based on the WHO 2022 criteria with an emphasis on the grey-zone lesions.
Ann Diagn Pathol
August 2024
Department of Pathology, Histopathology Division, Sir Ganga Ram Hospital, New Delhi, India. Electronic address:
Follicular-patterned thyroid nodules (FPTN) are classified byWHO-2022 into benign, borderline and malignant categories. There are however, grey-zone lesions that pose a diagnostic challenge due to ambiguity in defining criteria and inter-observer variability. WHO-2022 has enumerated specific diagnostic criteria for these lesions.
View Article and Find Full Text PDF[Evaluation of accuracy of pathological diagnosis based on thyroid core needle biopsy].
Beijing Da Xue Xue Bao Yi Xue Ban
April 2023
Department of Pathology, Peking University First Hospital, Beijing 100034, China.
Objective: To explore the protocol for diagnosing thyroid nodules based on core needle biopsy (CNB) and study the biomarkers' application in distinguishing indeterminate samples.
Methods: Patients with thyroid nodules treated at Peking University First Hospital from 2015 to 2020 were reviewed. In the study, 598 cases with CNB and matched resected specimens were retrieved.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!